• Publications
  • Influence
Randomized, Double-Blind Study of the Safety, Tolerability, and Efficacy of Tafenoquine versus Mefloquine for Malaria Prophylaxis in Nonimmune Subjects
ABSTRACT This study represents the first phase III trial of the safety, tolerability, and effectiveness of tafenoquine for malaria prophylaxis. In a randomized (3:1), double-blinded study, AustralianExpand
  • 84
  • 3
Long term immunity to live attenuated Japanese encephalitis chimeric virus vaccine
In a randomized, double-blind study, 202 healthy adults were randomized to receive a live, attenuated Japanese encephalitis chimeric virus vaccine (JE-CV) and placebo 28 days apart in a cross-overExpand
  • 36
  • 3
Treatment of acute vivax malaria with tafenoquine.
Tafenoquine is an 8-aminoquiniline related to primaquine with pre-clinical activity against a range of malaria species. We treated two acute cases of vivax malaria with tafenoquine (800 mg over threeExpand
  • 85
  • 1
Comparison of tafenoquine (WR238605) and primaquine in the post-exposure (terminal) prophylaxis of vivax malaria in Australian Defence Force personnel.
On return from duty in North Solomons Province (including Bougainville Island), Papua New Guinea, 586 Australian Defence Force personnel received either primaquine (14-d) or tafenoquine (3-d)Expand
  • 40
  • 1
Mefloquine and doxycycline malaria prophylaxis in Australian soldiers in East Timor
Objectives: To describe the tolerability of mefloquine in Australian soldiers for malaria prophylaxis, including a comparison with doxycycline.
  • 32
  • 1
  • PDF
Tafenoquine for the treatment of recurrent Plasmodium vivax malaria.
Tafenoquine was used to treat Plasmodium vivax malaria cases who had previously failed treatment with chloroquine and primaquine. Chloroquine was followed by a loading dose of tafenoquine (200 mgExpand
  • 32
  • PDF
Population Pharmacokinetics of Tafenoquine during Malaria Prophylaxis in Healthy Subjects
ABSTRACT The population pharmacokinetics of tafenoquine were studied in Australian soldiers taking tafenoquine for malarial prophylaxis. The subjects (476 males and 14 females) received a loadingExpand
  • 22
  • PDF
Population pharmacokinetics of mefloquine in military personnel for prophylaxis against malaria infection during field deployment
ObjectiveThe purpose of this study was to determine the population pharmacokinetics of mefloquine in healthy military personnel during prophylaxis for malaria infections.MethodsThe subjects wereExpand
  • 22
Gender differences in gastrointestinal disturbances and plasma concentrations of tafenoquine in healthy volunteers after tafenoquine administration for post-exposure vivax malaria prophylaxis.
In an open-label sequential cohort study, we compared gastrointestinal (GI) disturbances and plasma tafenoquine concentrations after administration of single-dose (400mg daily x 3 days; n=76 males,Expand
  • 13
Lack of in vitro effect of ivermectin on Plasmodium falciparum.
The in vitro activity of ivermectin was assessed against the K1 isolate of Plasmodium falciparum. The mean IC50 and IC90 of ivermectin were 8.0 and 35.0 microg/ml, respectively. These resultsExpand
  • 10
  • PDF