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Does small-conductance calcium-activated potassium channel contribute to cardiac repolarization?
TLDR
In rat, dog and human ventricular cells under normal physiological conditions--though present--SK2 channels are not active and do not contribute to action potential repolarization, contradicting studies on cardiac "repolarization reserve".
Effects of endothelin-1 on calcium and potassium currents in undiseased human ventricular myocytes
TLDR
The present results indicate that in undiseased human ventricular myocytes ET-1 inhibits both ICa-L and IKr; however, the degree of suppression of the two currents is different.
Effects of SEA0400 and KB-R7943 on Na+/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes
TLDR
SEA0400 appears to be a suitable tool to study the role of INa/Ca in Ca2+ handling in canine cardiac cells and accelerated inactivation of ICa, retarded recovery from inactivation and shifted the voltage dependence of inactivation towards more negative voltages.
Selective inhibition of sodium–calcium exchanger by SEA‐0400 decreases early and delayed afterdepolarization in canine heart
TLDR
It is concluded that, through the reduction of calcium overload, specific inhibition of the NCX current by SEA‐0400 may abolish triggered arrhythmias.
Diabetes mellitus attenuates the repolarization reserve in mammalian heart.
TLDR
It is concluded that type 1 diabetes mellitus, although only moderately, lengthens ventricular repolarization, attenuates the repolarized reserve by decreasing I(to) and I(Ks) currents, and thereby may markedly enhance the risk of sudden cardiac death.
Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium versus midmyocardium
TLDR
In the canine heart, the EPI-MID differences in ion current densities were proportional to differences in channel protein expression, and similar results were obtained in human hearts, although the HERG was more abundant in the E PI than in the MID layer.
Activation of transient receptor potential vanilloid-3 inhibits human hair growth.
TLDR
The findings collectively support the concept that TRPV3 signaling is a significant player in human hair growth control and and the related intracellular signaling mechanism might function as a promising target for pharmacological manipulations of clinically relevant hair growth disorders.
Effects of thymol on calcium and potassium currents in canine and human ventricular cardiomyocytes
TLDR
Thymol suppressed cardiac ionic channels in a concentration‐dependent manner, however, both drug‐sensitivities as well as the mechanism of action seems to be different when blocking calcium and potassium channels.
Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium.
TLDR
The results suggest that marked apico-basal electrical inhomogeneity exists in the canine-and probably in the human-ventricular myocardium, which may result in increased dispersion, and therefore, cannot be ignored when interpreting ECG recordings, pathological alterations, or drug effects.
Dynamics of the late Na(+) current during cardiac action potential and its contribution to afterdepolarizations.
TLDR
In conclusion, INa,L contributes a significantly large inward current that prolongs APD and unbalances the Ca(2+) homeostasis to cause arrhythmogenic APs.
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