Diabetes mellitus attenuates the repolarization reserve in mammalian heart.
- C. Lengyel, L. Virág, A. Varró
- Biology, MedicineCardiovascular Research
- 1 February 2007
Effects of SEA0400 and KB-R7943 on Na+/Ca2+ exchange current and L-type Ca2+ current in canine ventricular cardiomyocytes
- P. Birinyi, K. Acsai, P. Nanasi
- BiologyNaunyn-Schmiedeberg's Archives of Pharmacology
- 6 August 2005
SEA0400 appears to be a suitable tool to study the role of INa/Ca in Ca2+ handling in canine cardiac cells and accelerated inactivation of ICa, retarded recovery from inactivation and shifted the voltage dependence of inactivation towards more negative voltages.
Selective inhibition of sodium–calcium exchanger by SEA‐0400 decreases early and delayed afterdepolarization in canine heart
- Zsolt Nagy, L. Virág, A. Varró
- BiologyBritish Journal of Pharmacology
- 1 December 2004
It is concluded that, through the reduction of calcium overload, specific inhibition of the NCX current by SEA‐0400 may abolish triggered arrhythmias.
Asymmetrical distribution of ion channels in canine and human left-ventricular wall: epicardium versus midmyocardium
- G. Szabó, N. Szentandrassy, P. Nanasi
- BiologyPflügers Archiv
- 11 June 2005
In the canine heart, the EPI-MID differences in ion current densities were proportional to differences in channel protein expression, and similar results were obtained in human hearts, although the HERG was more abundant in the E PI than in the MID layer.
Activation of transient receptor potential vanilloid-3 inhibits human hair growth.
- I. Borbiro, E. Lisztes, T. Bíró
- BiologyJournal of Investigative Dermatology
- 1 August 2011
The findings collectively support the concept that TRPV3 signaling is a significant player in human hair growth control and and the related intracellular signaling mechanism might function as a promising target for pharmacological manipulations of clinically relevant hair growth disorders.
Apico-basal inhomogeneity in distribution of ion channels in canine and human ventricular myocardium.
- Norbert Szentadrassy, T. Bányász, P. Nanasi
- BiologyCardiovascular Research
- 1 March 2005
Endocardial versus epicardial differences in L-type calcium current in canine ventricular myocytes studied by action potential voltage clamp.
- T. Bányász, László Fülöp, J. Magyar, N. Szentandrassy, A. Varró, P. Nanasi
- Biology, MedicineCardiovascular Research
- 1 April 2003
Reverse rate dependency is an intrinsic property of canine cardiac preparations.
- T. Bányász, B. Horváth, P. Nanasi
- Biology, MedicineCardiovascular Research
- 1 November 2009
RRD can be interpreted as a consequence of the relationship between I(m) and APD and, as such, is expected in all species having positive APD-CL relationship, implying that the development of agents prolonging APD with direct rate dependency, or even completely devoid of RRD, may be difficult to achieve.
Effects of thymol on calcium and potassium currents in canine and human ventricular cardiomyocytes
- J. Magyar, N. Szentandrassy, T. Bányász, László Fülöp, A. Varró, P. Nanasi
- Biology, MedicineBritish Journal of Pharmacology
- 1 May 2002
Thymol suppressed cardiac ionic channels in a concentration‐dependent manner, however, both drug‐sensitivities as well as the mechanism of action seems to be different when blocking calcium and potassium channels.
...
...