Author pages are created from data sourced from our academic publisher partnerships and public sources.
New insights into the mechanisms of RNA recombination.
RNA plays many different roles in biological systems. characteristic marker mutations from the parental RNAs. One of RNAs most intriguing features is the ability to Following the initial… Expand
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line.
Overexpression of erbB2 in breast tumors is associated with poor prognosis and is a target of receptor-oriented cancer therapy. Trastuzumab (Herceptin), a monoclonal antibody against a… Expand
The dependence of viral RNA replication on co-opted host factors
Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoprotein… Expand
Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction
The erbB/HER family of transmembrane receptor tyrosine kinases (RTKs) mediate cellular responses to epidermal growth factor (EGF) and related ligands. We have imaged the early stages of RTK-dependent… Expand
Proteomics Analysis of the Tombusvirus Replicase: Hsp70 Molecular Chaperone Is Associated with the Replicase and Enhances Viral RNA Replication
ABSTRACT Plus-strand RNA virus replication occurs via the assembly of viral replicase complexes involving multiple viral and host proteins. To identify host proteins present in the cucumber necrosis… Expand
A replication silencer element in a plus‐strand RNA virus
Replication represents a key step in the infectious cycles of RNA viruses. Here we describe a regulatory RNA element, termed replication silencer, that can down‐regulate complementary RNA synthesis… Expand
A Key Role for Heat Shock Protein 70 in the Localization and Insertion of Tombusvirus Replication Proteins to Intracellular Membranes
ABSTRACT Plus-stranded RNA viruses coopt host proteins to promote their robust replication in infected hosts. Tomato bushy stunt tombusvirus (TBSV) is a model virus that can replicate a small… Expand
Advances in the molecular biology of tombusviruses: gene expression, genome replication, and recombination.
The tombusviruses are among the most extensively studied messenger-sensed RNA plant viruses. Over the past decade, there have been numerous important advances in our understanding of the molecular… Expand
Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA viruses.
- T. Panavas, Elena Servienė, J. Brasher, P. Nagy
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 17 May 2005
Viruses are devastating pathogens of humans, animals, and plants. To further our understanding of how viruses use the resources of infected cells, we systematically tested the yeast… Expand
The role of the p33:p33/p92 interaction domain in RNA replication and intracellular localization of p33 and p92 proteins of Cucumber necrosis tombusvirus.
Replication of plus-stranded RNA viruses is performed by the viral replicase complex, which, together with the viral RNA, must be targeted to intracellular membranes, where replication takes place in… Expand