• Publications
  • Influence
New insights into the mechanisms of RNA recombination.
RNA plays many different roles in biological systems. characteristic marker mutations from the parental RNAs. One of RNAs most intriguing features is the ability to Following the initialExpand
  • 364
  • 29
  • PDF
Decreased accessibility and lack of activation of ErbB2 in JIMT-1, a herceptin-resistant, MUC4-expressing breast cancer cell line.
Overexpression of erbB2 in breast tumors is associated with poor prognosis and is a target of receptor-oriented cancer therapy. Trastuzumab (Herceptin), a monoclonal antibody against aExpand
  • 435
  • 24
  • PDF
The dependence of viral RNA replication on co-opted host factors
Positive-sense RNA ((+)RNA) viruses such as hepatitis C virus exploit host cells by subverting host proteins, remodelling subcellular membranes, co-opting and modulating protein and ribonucleoproteinExpand
  • 312
  • 19
Quantum dot ligands provide new insights into erbB/HER receptor–mediated signal transduction
The erbB/HER family of transmembrane receptor tyrosine kinases (RTKs) mediate cellular responses to epidermal growth factor (EGF) and related ligands. We have imaged the early stages of RTK-dependentExpand
  • 749
  • 15
Proteomics Analysis of the Tombusvirus Replicase: Hsp70 Molecular Chaperone Is Associated with the Replicase and Enhances Viral RNA Replication
ABSTRACT Plus-strand RNA virus replication occurs via the assembly of viral replicase complexes involving multiple viral and host proteins. To identify host proteins present in the cucumber necrosisExpand
  • 175
  • 15
A replication silencer element in a plus‐strand RNA virus
Replication represents a key step in the infectious cycles of RNA viruses. Here we describe a regulatory RNA element, termed replication silencer, that can down‐regulate complementary RNA synthesisExpand
  • 127
  • 15
A Key Role for Heat Shock Protein 70 in the Localization and Insertion of Tombusvirus Replication Proteins to Intracellular Membranes
ABSTRACT Plus-stranded RNA viruses coopt host proteins to promote their robust replication in infected hosts. Tomato bushy stunt tombusvirus (TBSV) is a model virus that can replicate a smallExpand
  • 128
  • 14
Advances in the molecular biology of tombusviruses: gene expression, genome replication, and recombination.
  • K. A. White, P. Nagy
  • Biology, Medicine
  • Progress in nucleic acid research and molecular…
  • 2004
The tombusviruses are among the most extensively studied messenger-sensed RNA plant viruses. Over the past decade, there have been numerous important advances in our understanding of the molecularExpand
  • 203
  • 13
Yeast genome-wide screen reveals dissimilar sets of host genes affecting replication of RNA viruses.
Viruses are devastating pathogens of humans, animals, and plants. To further our understanding of how viruses use the resources of infected cells, we systematically tested the yeastExpand
  • 199
  • 12
The role of the p33:p33/p92 interaction domain in RNA replication and intracellular localization of p33 and p92 proteins of Cucumber necrosis tombusvirus.
Replication of plus-stranded RNA viruses is performed by the viral replicase complex, which, together with the viral RNA, must be targeted to intracellular membranes, where replication takes place inExpand
  • 166
  • 12
  • PDF