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Journals and Conferences
Clinical studies with the Abl tyrosine kinase inhibitor STI-571 in chronic myeloid leukemia demonstrate that many patients with advanced stage disease respond initially but then relapse. Through… (More)
Certain proteins or activities are present in mitotic cells but not in interphase cells. These proteins may be synthesized or activated, or both, just prior to mitosis and are responsible for the… (More)
Further evidence is put forward for the inducibility of chromosome condensation, particularly its consequences in interphase cells that are not ready for mitosis.
DNA synthesis and mitosis are inducible in multinucleate HeLa cells formed by fusion between cells in different phases of the life cycle.
Intratumoral heterogeneity contributes to cancer drug resistance, but the underlying mechanisms are not understood. Single-cell analyses of patient-derived models and clinical samples from… (More)
The kinetochore is a specialized structure at the centromere of eukaryotic chromosomes that attaches chromosomes to the mitotic spindle1,2. Recently, several lines of evidence have suggested that… (More)
We have determined that the major mitotic phosphoprotein in chromosomes recognized by the antiphosphoprotein antibody MPM-2 is the 170-kDa isoform of topoisomerase II (topo II), the isoform… (More)
The MPM2 monoclonal antibody binds to a phospho amino acid-containing epitope present on more than 40 proteins of M-phase eukaryotic cells. We have developed a technique for cloning cDNAs encoding… (More)
Protein phosphorylation has been suggested as an important control mechanism for the events leading toward the initiation and completion of mitosis. Using a monoclonal antibody recognizing a class of… (More)
When HeLa cells were grown in the presence of nitrous oxide (N(2)O) under pressure (80 lb/in(2)) mitosis was inhibited and the chromosomes displayed a typical colchicine metaphase (c-metaphase)… (More)