P. Nadeau

Publications14
h-index5
Citations180
Highly Influential Citations4
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The effect of tissue and cellular pH on the selective biodistribution of porphyrin-type photochemotherapeutic agents: a volumetric titration study.
A COMPARISON OF FLUORESCENCE METHODS USED IN THE PHARMACOKINETIC STUDIES OF Zn(II)PHTHALOCYANINE IN MICE
TLDR
The in vivo measurements at two different anatomical sites showed pharmacokinetic behavior that reflects an overall integrated fluorescence originating from several tissue sites, consistent with previous findings on the pharmacokinetics of ZnPc.
CLEARANCE TIMES OF PORPHYRIN DERIVATIVES FROM MICE AS MEASURED BY in vivo FLUORESCENCE SPECTROSCOPY
Abstract
ON THE SOURCE OF THE OSCILLATIONS OBSERVED DURING in vivo ZINC PHTHALOCYANINE FLUORESCENCE PHARMACOKINETIC MEASUREMENTS IN MICE
TLDR
Surface‐detected fluorescence spectroscopy can be used to monitor the pharmacokinetics of uptake and clearance of red‐absorbing fluorophores such as zinc(II) phthalocyanine (ZnPc) in vivo, but it is important to be aware of the possibility of such artifactual contributions to in vivo fluorescence pharmacokinetic measurements.
Lidocaine plasma concentrations during and after endoscopic procedures.
TLDR
D doses of this topical anaesthetic up to 16 mg/kg can be safely given during endoscopic procedures to patients with normal hepatic and cardiovascular functions, however, patients with liver metastases should be considered at high risk even if their liver function tests are normal.
Assessment of noncoherent light sources for photodynamic therapy
Several types of non-coherent light sources can be used for dermatological applications of photodynamic therapy (PDT). Such sources are relatively inexpensive, stable, and easy to operate, requiring…
ASSESSMENT AND COMPARISON OF SPECTRAL AND SPATIAL EMISSION CHARACTERISTICSOF NON-COHERENT LIGHT SOURCES FOR USE IN PHOTOMEDICINE
CLEARANCE TIMES OF PORPHYRIN DERIVATIVES FROM MICE AS MEASURED BY in vivo FLUORESCENCE SPECTROSCOPY
Abstract— The clearance times of 17 different porphyrin derivatives from SKH:HR‐1 mice have been measured using the technique of in vivo fluorescence spectroscopy. This technique monitors the in vivo…
Characterization of the fluorescence lifetimes of the ionic species found in aqueous solutions of hematoporphyrin IX as a function of pH
FOUND IN AQUEOUS SOLUTIONS OF HEMATOPORPHYRIN IX AS A FUNCTION OF pH. Pierre Nadeau and Roy H. Pottier, Department of Chemistry and Chemical Engineering, The Royal Military College of Canada,…
A comparison of fluorescence excitation sources for in vivo pharmacokinetic measurements of the photodynamic therapy model photosensitizer hematoporphyrin. IX
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