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Nonclinical Model for Assessing Gastric Effects of Bisphosphonates
- M. A. Blank, B. L. Ems, +4 authors P. N. Smith
- Digestive Diseases and Sciences
- 1 February 1997
Gastrointestinal intolerance has been associatedwith amino bisphosphonate therapy in the clinic. Theobjective of this study was to develop a model forassessing bisphosphonateinduced gastric damage… Expand
Risedronate treatment does not increase microdamage in the canine femoral neck.
Cortical and trabecular bone from the femoral neck of 24 adult female beagle dogs was examined for microdamage following 2 years of treatment with risedronate (NE-58095). Specimens of the femoral… Expand
The ferret as a small animal model with BMU-based remodeling for skeletal research.
UNLABELLED The need exists for a small animal model with bone metabolic unit (BMU)-based remodeling to mimic the bone loss found in postmenopausal women. The purpose of this investigation was to… Expand
Use of methoxyfluorane to surgically implant transmitters in muskrats
We tested the feasibility of using methoxyflurane as a field anesthetic on 12 adult muskrats (Ondatra zibethicus) from May through September 1987. Transmitters were successfully implanted into the… Expand