• Publications
  • Influence
Economic costs of the foot and mouth disease outbreak in the United Kingdom in 2001.
The authors present estimates of the economic costs to agriculture and industries affected by tourism of the outbreak of foot and mouth disease (FMD) in the United Kingdom (UK) in 2001. The losses toExpand
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Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress.
Curcumin, an anti-inflammatory and antioxidant compound, was evaluated for its ability to suppress acute carbon tetrachloride-induced liver damage. Acute hepatotoxicity was induced by oralExpand
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Silymarin protects against paracetamol‐induced lipid peroxidation and liver damage
The effect of silymarin on liver damage induced by acetaminophen (APAP) intoxication was studied. Wistar male rats pretreated (72 h) with 3‐methylcholantrene (3‐MC) (20 mg kg−1 body wt. i.p.) wereExpand
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Tight junction proteins ZO-1, ZO-2, and occludin along isolated renal tubules.
BACKGROUND Tight junctions play a critical role in tubular function. In mammalian kidney, the transepithelial electrical resistance and the complexity of the tight junction increase from the proximalExpand
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Prevention by silymarin of membrane alterations in acute CCI4 liver damage
The effect of silymarin on liver lipid peroxidation and membrane lipid alterations induced by an acute dose of CCI4 was studied. Four groups of animals were treated with CCI4, CCI4 + silymarin,Expand
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Beneficial drugs for liver diseases
Liver diseases are a major problem of worldwide proportions. However, the number of drugs actually used successfully in humans is very small. In this review some of the most promising/studied drugsExpand
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Regulation of nitric oxide synthesis in the liver
  • P. Muriel
  • Chemistry, Medicine
  • Journal of applied toxicology : JAT
  • 1 May 2000
Nitric oxide signalling during the past two decades has been one of the most rapidly growing areas in biology. This simple free radical gas can regulate an ever‐growing list of biological processes.Expand
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Beneficial effects of naringenin in liver diseases: Molecular mechanisms
Liver diseases are caused by different etiological agents, mainly alcohol consumption, viruses, drug intoxication or malnutrition. Frequently, liver diseases are initiated by oxidative stress andExpand
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Nitric oxide protection of rat liver from lipid peroxidation, collagen accumulation, and liver damage induced by carbon tetrachloride.
  • P. Muriel
  • Medicine, Chemistry
  • Biochemical pharmacology
  • 15 September 1998
The aim of this work was to determine if the inhibition or stimulation of NO synthesis modulates liver damage induced by the chronic administration of CCl4. CCl4 was administered three times a weekExpand
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NF‐κB in liver diseases: a target for drug therapy
  • P. Muriel
  • Medicine, Chemistry
  • Journal of applied toxicology : JAT
  • 1 March 2009
There are five nuclear factor‐κB (NF‐κB) transcription factors with important roles in innate immunity, liver inflammation, fibrosis and apoptosis prevention. Several inhibitors of NF‐κB, likeExpand
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