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Quantification of protein modification by oxidants.
Proteins are major targets for oxidative damage due to their abundance and rapid rates of reaction with a wide range of radicals and excited state species, such as singlet oxygen. Exposure ofExpand
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Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial
Background Olive plant leaves (Olea europaea L.) have been used for centuries in folk medicine to treat diabetes, but there are very limited data examining the effects of olive polyphenols on glucoseExpand
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Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus.
OBJECTIVE To examine protein oxidation in systemic lupus erythematosus (SLE) and to correlate levels of protein oxidation products with disease activity. METHODS Serum was collected from SLEExpand
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High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase.
Smokers have an elevated risk of atherosclerosis but the origins of this elevated risk are incompletely defined, though evidence supports an accumulation of the oxidant-generating enzymeExpand
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Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
Elevated MPO (myeloperoxidase) levels are associated with multiple human inflammatory pathologies. MPO catalyses the oxidation of Cl−, Br− and SCN− by H2O2 to generate the powerful oxidantsExpand
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Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products.
Diabetic plasma contains elevated levels of glucose and various low-molecular-weight carbonyl compounds derived from the metabolism of glucose and related materials. These compounds react withExpand
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High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction
Abstract Elevated levels of myeloperoxidase (MPO) are associated with poor cardiovascular outcomes. MPO uses H2O2 to generate oxidants including HOCl and HOSCN, from chloride and thiocyanate (SCN−)Expand
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Large-Eddy Simulation of Separation Control for Flow over a Wall-Mounted Hump
This work describes an implicit large-eddy simulation (LES) for active control of flow over a wall-mounted hump. Both steady suction and oscillatory blowing and suction are compared to baselineExpand
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