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- Publications
- Influence
Quantification of protein modification by oxidants.
- C. Hawkins, P. Morgan, M. Davies
- Chemistry, Medicine
- Free radical biology & medicine
- 15 April 2009
Proteins are major targets for oxidative damage due to their abundance and rapid rates of reaction with a wide range of radicals and excited state species, such as singlet oxygen. Exposure of… Expand
Olive (Olea europaea L.) Leaf Polyphenols Improve Insulin Sensitivity in Middle-Aged Overweight Men: A Randomized, Placebo-Controlled, Crossover Trial
- M. de Bock, J. Derraik, +5 authors W. Cutfield
- Medicine
- PloS one
- 13 March 2013
Background Olive plant leaves (Olea europaea L.) have been used for centuries in folk medicine to treat diabetes, but there are very limited data examining the effects of olive polyphenols on glucose… Expand
Increased levels of serum protein oxidation and correlation with disease activity in systemic lupus erythematosus.
- P. Morgan, A. Sturgess, M. Davies
- Chemistry, Medicine
- Arthritis and rheumatism
- 1 July 2005
OBJECTIVE
To examine protein oxidation in systemic lupus erythematosus (SLE) and to correlate levels of protein oxidation products with disease activity.
METHODS
Serum was collected from SLE… Expand
High plasma thiocyanate levels in smokers are a key determinant of thiol oxidation induced by myeloperoxidase.
- P. Morgan, D. Pattison, +5 authors M. Davies
- Chemistry, Medicine
- Free radical biology & medicine
- 1 November 2011
Smokers have an elevated risk of atherosclerosis but the origins of this elevated risk are incompletely defined, though evidence supports an accumulation of the oxidant-generating enzyme… Expand
Selenium-containing amino acids are targets for myeloperoxidase-derived hypothiocyanous acid: determination of absolute rate constants and implications for biological damage
- Ojia Skaff, D. Pattison, +4 authors M. Davies
- Chemistry, Medicine
- The Biochemical journal
- 5 September 2011
Elevated MPO (myeloperoxidase) levels are associated with multiple human inflammatory pathologies. MPO catalyses the oxidation of Cl−, Br− and SCN− by H2O2 to generate the powerful oxidants… Expand
Inactivation of cellular enzymes by carbonyls and protein-bound glycation/glycoxidation products.
Diabetic plasma contains elevated levels of glucose and various low-molecular-weight carbonyl compounds derived from the metabolism of glucose and related materials. These compounds react with… Expand
High plasma thiocyanate levels are associated with enhanced myeloperoxidase-induced thiol oxidation and long-term survival in subjects following a first myocardial infarction
- P. Nedoboy, P. Morgan, T. Mocatta, A. Richards, C. Winterbourn, M. Davies
- Chemistry, Medicine
- Free radical research
- 22 July 2014
Abstract Elevated levels of myeloperoxidase (MPO) are associated with poor cardiovascular outcomes. MPO uses H2O2 to generate oxidants including HOCl and HOSCN, from chloride and thiocyanate (SCN−)… Expand
An Implicit LES Approach Based on High-order Compact Differencing and Filtering Schemes (Invited)
- M. Visbal, P. Morgan, D. Rizzetta
- Computer Science
- 23 June 2003
Large-Eddy Simulation of Separation Control for Flow Over a Wall-Mounted Hump
- P. Morgan, D. Rizzetta, M. Visbal
- Physics
- 6 June 2005
Large-Eddy Simulation of Separation Control for Flow over a Wall-Mounted Hump
- P. Morgan, D. Rizzetta, M. Visbal
- Mathematics
- 1 November 2007
This work describes an implicit large-eddy simulation (LES) for active control of flow over a wall-mounted hump. Both steady suction and oscillatory blowing and suction are compared to baseline… Expand