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The endonuclease activity of Mili fuels piRNA amplification that silences LINE1 elements
Piwi proteins and Piwi-interacting RNAs (piRNAs) have conserved functions in transposon silencing. The murine Piwi proteins Mili and Miwi2 (also called Piwil2 and Piwil4, respectively) directExpand
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The RNA m6A Reader YTHDF2 Is Essential for the Post-transcriptional Regulation of the Maternal Transcriptome and Oocyte Competence
Summary YTHDF2 binds and destabilizes N6-methyladenosine (m6A)-modified mRNA. The extent to which this branch of m6A RNA-regulatory pathway functions in vivo and contributes to mammalian developmentExpand
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Efficient Generation of Transgenic Mice with Intact Yeast Artificial Chromosomes by Intracytoplasmic Sperm Injection1
Abstract The production of animals with large transgenes is an increasingly valuable tool in biotechnology and for genetic studies, including the characterization and manipulation of large genes andExpand
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Generation and characterization of an Advillin-Cre driver mouse line
Progress in the somatosensory field has been restricted by the limited number of genetic tools available to study gene function in peripheral sensory neurons. Here we generated a Cre-driver mouseExpand
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Developmental consequences of sexual dimorphism during pre-implantation embryonic development.
Abnormalities of development potential arising from pre-implantation environment are not limited to in vitro culture (IVC) (for, i.e. in ruminants the large offspring syndrome produced by IVC), theyExpand
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Hyperglycemia‐induced apoptosis affects sex ratio of bovine and murine preimplantation embryos
The effect of glucose in the medium used during in vitro culture on both cell death by apoptosis and the sex ratio of bovine blastocysts derived from in vitro‐matured and in vitro‐fertilized oocytesExpand
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Architectural defects in pronuclei of mouse nuclear transplant embryos
Reprogramming somatic nuclear function by transplantation of nuclei into recipient oocytes is associated with a morphological remodeling of the somatic nucleus. Successful cloning of animals byExpand
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Influence of sperm pretreatment on the efficiency of intracytoplasmic sperm injection in pigs.
The purpose of this study was to determine the influence of sperm pretreatment on the efficiency of intracytoplasmic sperm injection (ICSI) in pigs. This was done by examining the effect of 1) theExpand
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