• Publications
  • Influence
Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes
A set of guidelines for the selection and interpretation of the methods that can be used by investigators who are attempting to examine macroautophagy and related processes, as well as by reviewers who need to provide realistic and reasonable critiques of papers that investigate these processes are presented. Expand
SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.
It is shown that the mitochondrial NAD-dependent deacetylase SIRT3 is a crucial regulator of the Warburg effect, and it is found that Sirt3 overexpression represses glycolysis and proliferation in breast cancer cells, providing a metabolic mechanism for tumor suppression. Expand
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
There continues to be confusion regarding acceptable methods to measure autophagy, especially in multicellular eukaryotes, so it is important to update guidelines for monitoring autophagic activity in different organisms. Expand
Amyloid-β overproduction causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins
  • Xinglong Wang, Bo Su, +5 authors Xiongwei Zhu
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences
  • 9 December 2008
APP, through amyloid β production, causes an imbalance of mitochondrial fission/fusion that results in mitochondrial fragmentation and abnormal distribution, which contributes to mitochondrial and neuronal dysfunction. Expand
Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology.
Evidence indicating that mitochondrial dysfunction has an early and preponderant role in Alzheimer's disease is discussed, and the link between mitochondrial dysfunction and autophagy in Alzheimer’s disease is also discussed. Expand
Insulin in Central Nervous System: More than Just a Peripheral Hormone
This work aims to integrate the metabolic, neuromodulatory, and neuroprotective roles of insulin in two age-related pathologies: diabetes and AD, both in terms of intracellular signaling and potential therapeutic approach. Expand
Doxorubicin: the good, the bad and the ugly effect.
The mechanisms underlying not only DOX beneficial effects but also its toxic outcomes are discussed, and some potential strategies to attenuate DOX-induced toxicity will be debated. Expand
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.
Alzheimer disease (AD) is a neurodegenerative disease which is characterized by the presence of extracellular senile plaques mainly composed of amyloid-beta peptide (Abeta), intracellularExpand
Involvement of Oxidative Stress in Alzheimer Disease
A combination of dietary regimen of low total calorie and rich antioxidant nutrients and maintaining physical and intellectual activities may ultimately prove to be one of the most efficacious strategies for AD prevention. Expand
Molecular mechanisms beyond glucose transport in diabetes-related male infertility.
An overview of the clinical significance of DM in the male reproductive health with emphasis on the molecular mechanisms beyond glucose fluctuation and transport in testicular cells is presented. Expand