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Ancient Admixture in Human History
A suite of methods for learning about population mixtures are presented, implemented in a software package called ADMIXTOOLS, that support formal tests for whether mixture occurred and make it possible to infer proportions and dates of mixture. Expand
The complete genome sequence of a Neanderthal from the Altai Mountains
Kay Prüfer, Fernando Racimo, Nick Patterson, Flora Jay, Sriram Sankararaman, Susanna Sawyer, Anja Heinze, Gabriel Renaud, Peter H. Sudmant, Cesare de Filippo, Heng Li, Swapan Mallick, MichaelExpand
Genome sequence of a 45,000-year-old modern human from western Siberia
We present the high-quality genome sequence of a ∼45,000-year-old modern human male from Siberia. This individual derives from a population that lived before—or simultaneously with—the separation ofExpand
Inferring Admixture Histories of Human Populations Using Linkage Disequilibrium
A new weighted LD statistic is presented that can be used to infer mixture proportions as well as dates with fewer constraints on reference populations than previous methods and can uncover phylogenetic relationships among populations by comparing weighted LD curves obtained using a suite of references. Expand
The complete genome sequence of a Neandertal from the Altai Mountains
It is shown that interbreeding, albeit of low magnitude, occurred among many hominin groups in the Late Pleistocene and a definitive list of substitutions that became fixed in modern humans after their separation from the ancestors of Neanderthals and Denisovans is established. Expand
Complete Khoisan and Bantu genomes from southern Africa
The extent of whole-genome and exome diversity among the five men, reporting 1.3 million novel DNA differences genome-wide, including 13,146 novel amino acid variants, suggests the Bushmen seem to be more different from each other than, for example, a European and an Asian. Expand
The History of African Gene Flow into Southern Europeans, Levantines, and Jews
Genetic data is analyzed from about 40 West Eurasian groups to show that almost all Southern Europeans have inherited 1%–3% African ancestry with an average mixture date of around 55 generations ago, consistent with North African gene flow at the end of the Roman Empire and subsequent Arab migrations. Expand
Genetic evidence for recent population mixture in India.
Most Indian groups descend from a mixture of two genetically divergent populations: Ancestral North Indians (ANI) related to Central Asians, Middle Easterners, Caucasians, and Europeans; andExpand
Reconstructing Austronesian population history in Island Southeast Asia
It is shown that all sampled Austronesian groups harbor ancestry that is more closely related to aboriginal Taiwanese than to any present-day mainland population, suggesting that either there was once a substantial Austro-Asiatic presence in Island Southeast Asia, or Austronesians migrated to and through the mainland, admixing there before continuing to western Indonesia. Expand
Corticotrophin-Releasing Hormone Type 1 Receptor Gene (CRHR1) Variants Predict Posttraumatic Stress Disorder Onset and Course in Pediatric Injury Patients
Support is added for the role of CRHR1 in the stress response following potentially traumatic event exposure in youth by indicating that multiple SNPs were associated with acute symptoms at a univariate level, and after correction for multiple testing, rs12944712 was significantly related to acute PTSD symptoms. Expand