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Nocturnal frontal lobe epilepsy. A clinical and polygraphic overview of 100 consecutive cases.
- F. Provini, G. Plazzi, P. Tinuper, S. Vandi, E. Lugaresi, P. Montagna
- Medicine, PsychologyBrain : a journal of neurology
- 1 June 1999
It is believed that the detailed clinical and videoEEG characterization of patients with NFLE represents the first step towards a better understanding of the pathogenic mechanisms and different clinical outcomes of the various seizure types that constitute the syndrome.
Toward a better definition of the restless legs syndrome
- A. Walters, M. Aldrich, M. Zucconi
- MedicineMovement disorders : official journal of the…
- 1 September 1995
Features commonly seen in RLS include sleep disturbance, periodic limb movements in sleep and similar involuntary movements while awake, a normal neurological examination in the idiopathic from, a tendency for the symptoms to be worse in middle to older age, and, in some cases, a family history suggestive of an autosomal dominant mode of inheritance.
Fatal familial insomnia and familial Creutzfeldt-Jakob disease: disease phenotype determined by a DNA polymorphism.
Two distinct disease phenotypes linked to a single pathogenic mutation can be determined by a common polymorphism.
Evidence for the Conformation of the Pathologic Isoform of the Prion Protein Enciphering and Propagating Prion Diversity
The results presented indicate that the conformation of PrP sc functions as a template in directing the formation of nascent PrPSc and suggest a mechanism to explain strains of prions where diversity is encrypted in the conformed PrP Sc.
Fatal familial insomnia and dysautonomia with selective degeneration of thalamic nuclei.
The thalamus is affected in diffuse degenerative processes of the nervous system and it has not been established whether a genetically determined degenerative disease may be limited in patients with this organ.
Treatment of restless legs syndrome: An evidence‐based review and implications for clinical practice
- C. Trenkwalder, W. Hening, C. Sampaio
- Medicine, PsychologyMovement disorders : official journal of the…
- 15 December 2008
An evidence‐based review of the medical literature on treatment modalities used to manage patients with RLS found that levodopa, ropinirole, pramipexole, cabergoline, pergolide, and gabapentin are considered efficacious for the treatment of RLS and oral iron is considered investigational; however, its efficacy appears to depend on the iron status of subjects.
Fatal familial insomnia, a prion disease with a mutation at codon 178 of the prion protein gene.
- R. Medori, H. Tritschler, P. Cortelli
- Medicine, BiologyThe New England journal of medicine
- 13 February 1992
Fatal familial insomnia is a prion disease with a mutation in codon 178 of the PrP gene, but the disease phenotype seems to differ from that of previously described kindreds with the same point mutation.
REM sleep behavior disorders in multiple system atrophy
It is shown that RBD represents the most common clinical sleep manifestation and polysomnographic finding in patients with MSA and can frequently herald the appearance of other MSA symptoms by years.
The official World Association of Sleep Medicine (WASM) standards for recording and scoring periodic leg movements in sleep (PLMS) and wakefulness (PLMW) developed in collaboration with a task force…