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Function, structure and therapeutic potential of complement C5a receptors
Complement fragment (C)5a is a 74 residue pro‐inflammatory polypeptide produced during activation of the complement cascade of serum proteins in response to foreign surfaces such as microorganismsExpand
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The Orphan Receptor C5L2 Has High Affinity Binding Sites for Complement Fragments C5a and C5a des-Arg74 *
  • S. Cain, P. Monk
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • 1 March 2002
The substantial variations in the responses of cells to the anaphylatoxin C5a and its desarginated form, C5adR74, suggest that more than one type of cell surface receptor for these ligands mightExpand
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International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors.
The activation of the complement cascade, a cornerstone of the innate immune response, produces a number of small (74-77 amino acid) fragments, originally termed anaphylatoxins, that are potentExpand
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  • Open Access
Identification of Amino Acid Residues in CD81 Critical for Interaction with Hepatitis C Virus Envelope Glycoprotein E2
ABSTRACT Human CD81 has been previously identified as the putative receptor for the hepatitis C virus envelope glycoprotein E2. The large extracellular loop (LEL) of human CD81 differs in four aminoExpand
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The Chemoattractant Receptor-like Protein C5L2 Binds the C3a des-Arg77/Acylation-stimulating Protein*
The orphan receptor C5L2 has recently been described as a high affinity binding protein for complement fragments C5a and C3a that, unlike the previously described C5a receptor (CD88), couples onlyExpand
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The human complement fragment receptor, C5L2, is a recycling decoy receptor
C5L2 is a 7 transmembrane domain receptor for complement fragment C5a that, unlike the classical C5a receptor, C5aR, does not couple to G proteins. However, in mice where C5L2 has been deleted, theExpand
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Cxc chemokine receptor expression on human endothelial cells.
CXC chemokines play a important role in the process of leukocyte recruitment and activation at sites of inflammation. However, recent evidence suggests that these molecules can also regulateExpand
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C5L2 Is a Functional Receptor for Acylation-stimulating Protein*
C5L2 binds acylation-stimulating protein (ASP) with high affinity and is expressed in ASP-responsive cells. Functionality of C5L2 has not yet been demonstrated. Here we show that C5L2 is expressed inExpand
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Microglia as potential contributors to motor neuron injury in amyotrophic lateral sclerosis
The central nervous system (CNS) is equipped with a variety of cell types, all of which are assigned particular roles during the development, maintenance, function and repair of neural tissue. OneExpand
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The Role of the N-terminal Domain of the Complement Fragment Receptor C5L2 in Ligand Binding*
C5L2 is a new cellular receptor found to interact with the human anaphylatoxins complement factor C5a and its C-terminal cleavage product C5a des Arg. The classical human C5a receptor (C5aR)Expand
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