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- Publications
- Influence
RAG-1-deficient mice have no mature B and T lymphocytes
- P. Mombaerts, J. Iacomini, R. Johnson, K. Herrup, V. Papaioannou
- Biology, Medicine
- Cell
- 6 March 1992
The V(D)J recombination activation gene RAG-1 was isolated on the basis of its ability to activate V(D)J recombination on an artificial substrate in fibroblasts. This property and the expression… Expand
Visualizing an Olfactory Sensory Map
- P. Mombaerts, F. Wang, +5 authors R. Axel
- Biology, Medicine
- Cell
- 15 November 1996
We have developed a genetic approach to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the olfactory bulb. Neurons expressing a specific… Expand
Genes and ligands for odorant, vomeronasal and taste receptors
- P. Mombaerts
- Chemistry, Biology
- Nature Reviews Neuroscience
- 1 April 2004
The chemical senses (smell and taste) have evolved complex repertoires of chemosensory receptors — G-protein coupled receptors with a seven-transmembrane domain structure. In the mouse, ∼1,000… Expand
Structure and Emergence of Specific Olfactory Glomeruli in the Mouse
- Steve M. Potter, C. Zheng, D. S. Koos, P. Feinstein, S. Fraser, P. Mombaerts
- Biology, Medicine
- The Journal of Neuroscience
- 15 December 2001
Olfactory sensory neurons (OSNs) expressing a given odorant receptor (OR) gene project their axons to a few specific glomeruli that reside at recognizable locations in the olfactory bulb. Connecting… Expand
Mice cloned from embryonic stem cells.
- T. Wakayama, I. Rodriguez, A. C. Perry, R. Yanagimachi, P. Mombaerts
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 21 December 1999
Cloning allows the asexual reproduction of selected individuals such that the offspring have an essentially identical nuclear genome. Cloning by nuclear transfer thus far has been reported only with… Expand
Detection of Near-Atmospheric Concentrations of CO2 by an Olfactory Subsystem in the Mouse
- J. Hu, Chun Zhong, +5 authors M. Luo
- Chemistry, Medicine
- Science
- 17 August 2007
Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations around… Expand
Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System
- T. C. Bozza, P. Feinstein, Chen Zheng, P. Mombaerts
- Biology, Medicine
- The Journal of Neuroscience
- 15 April 2002
Odorant receptors (ORs) mediate the interaction of odorous compounds with olfactory sensory neurons (OSNs) and influence the guidance of OSN axons to synaptic targets in the olfactory bulb (OB). OSNs… Expand
In Vivo Imaging of Neuronal Activity by Targeted Expression of a Genetically Encoded Probe in the Mouse
- T. Bozza, J. Mcgann, P. Mombaerts, M. Wachowiak
- Biology, Medicine
- Neuron
- 8 April 2004
Genetically encoded probes show great promise in permitting functional imaging of specified neuronal populations in the intact nervous system, yet their in vivo application has been limited. Here, we… Expand
Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
- P. Mombaerts, A. Clarke, +8 authors S. Tonegawa
- Biology
- Nature
- 19 November 1992
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+… Expand
Selective deletion of leptin receptor in neurons leads to obesity.
- P. Cohen, C. Zhao, +5 authors J. Friedman
- Biology, Medicine
- The Journal of clinical investigation
- 15 October 2001
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain,… Expand