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RAG-1-deficient mice have no mature B and T lymphocytes
The V(D)J recombination activation gene RAG-1 was isolated on the basis of its ability to activate V(D)J recombination on an artificial substrate in fibroblasts. This property and the expressionExpand
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Visualizing an Olfactory Sensory Map
We have developed a genetic approach to visualize axons from olfactory sensory neurons expressing a given odorant receptor, as they project to the olfactory bulb. Neurons expressing a specificExpand
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Genes and ligands for odorant, vomeronasal and taste receptors
  • P. Mombaerts
  • Chemistry, Biology
  • Nature Reviews Neuroscience
  • 1 April 2004
The chemical senses (smell and taste) have evolved complex repertoires of chemosensory receptors — G-protein coupled receptors with a seven-transmembrane domain structure. In the mouse, ∼1,000Expand
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Structure and Emergence of Specific Olfactory Glomeruli in the Mouse
Olfactory sensory neurons (OSNs) expressing a given odorant receptor (OR) gene project their axons to a few specific glomeruli that reside at recognizable locations in the olfactory bulb. ConnectingExpand
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Mice cloned from embryonic stem cells.
Cloning allows the asexual reproduction of selected individuals such that the offspring have an essentially identical nuclear genome. Cloning by nuclear transfer thus far has been reported only withExpand
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Detection of Near-Atmospheric Concentrations of CO2 by an Olfactory Subsystem in the Mouse
Carbon dioxide (CO2) is an important environmental cue for many organisms but is odorless to humans. It remains unclear whether the mammalian olfactory system can detect CO2 at concentrations aroundExpand
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Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System
Odorant receptors (ORs) mediate the interaction of odorous compounds with olfactory sensory neurons (OSNs) and influence the guidance of OSN axons to synaptic targets in the olfactory bulb (OB). OSNsExpand
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In Vivo Imaging of Neuronal Activity by Targeted Expression of a Genetically Encoded Probe in the Mouse
Genetically encoded probes show great promise in permitting functional imaging of specified neuronal populations in the intact nervous system, yet their in vivo application has been limited. Here, weExpand
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Mutations in T-cell antigen receptor genes α and β block thymocyte development at different stages
Analysis of mice carrying mutant T-cell antigen receptor (TCP) genes indicates that TCP-β gene rearrangement or expression is critical for the differentiation of CD4− CD8− thymocytes to CD4+CD8+Expand
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Selective deletion of leptin receptor in neurons leads to obesity.
Animals with mutations in the leptin receptor (ObR) exhibit an obese phenotype that is indistinguishable from that of leptin deficient ob/ob mice. ObR is expressed in many tissues, including brain,Expand
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