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Genes and ligands for odorant, vomeronasal and taste receptors
Targeted expression of the green fluorescent protein in chemosensory cells is a promising approach to achieve this objective of characterized receptor–ligand interactions.
Structure and Emergence of Specific Olfactory Glomeruli in the Mouse
Three-dimensional reconstructions of OSNs constructed by gene targeting novel strains of mice in which either all OSNs or those that express a specific OR gene also produce green fluorescent protein (GFP) or a fusion of tau with GFP show a high degree of morphological variability of mature glomeruli receiving axonal input from OR-expressing OSNs and of the pathways taken by the axons to thoseglomeruli.
Mice cloned from embryonic stem cells.
It is shown that late-passage ES cells can be used to produce viable cloned mice and provide a link between the technologies of ES cells and animal cloning, suggesting that it may be possible to clone from a single cell a large number of individuals over an extended period.
Detection of Near-Atmospheric Concentrations of CO2 by an Olfactory Subsystem in the Mouse
It is concluded that mice detect CO2 at near-atmospheric concentrations through the olfactory subsystem of GC-D+ neurons, and this sensitive CO2 detection required CAII activity.
Odorant Receptor Expression Defines Functional Units in the Mouse Olfactory System
The data provide evidence that ORs determine both odorant specificity and axonal convergence and thus direct functionally similar afferents to form particular glomeruli and confirm and extend the notion that OR expression provides a molecular basis for the formation and arrangement of glomerular functional units.
Selective deletion of leptin receptor in neurons leads to obesity.
The data suggest that the brain is a direct target for the weight-reducing and neuroendocrine effects of leptin and that the liver abnormalities of db/db mice are secondary to defective leptin signaling in the brain.