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Aripiprazole, a Novel Antipsychotic, Is a High-Affinity Partial Agonist at Human Dopamine D2 Receptors
TLDR
These results, together with previous studies demonstrating partial agonist activity at serotonin 5-hydroxytryptamine (5-HT)1A receptors and antagonist activity at 5-HT2A receptors, support the identification of aripiprazole as a dopamine-serotonin system stabilizer. Expand
Basic Neurochemistry: Molecular, Cellular and Medical Aspects
Part 1 Neural membranes: neurocellular anatomy cell membrane structure and functions membrane transport electrical excitability and ion channels lipids myelin formation, structure and biochemistryExpand
Quantitative autoradiographic localization of the D1 and D2 subtypes of dopamine receptors in rat brain
The distribution of D1 and D2 receptors was studied in coronal sections of rat brain, using quantitative autoradiography. D1 receptors were labeled with 1.8 nM 3H-SKF-83566 (a brominated analog ofExpand
Developmental switch in the expression of NMDA receptors occurs in vivo and in vitro
TLDR
A developmental switch in the sensitivity ofNMDA receptors to the novel antagonist ifenprodil is characterized using ligand binding assays with rat brain membranes and voltage-clamp recording of Xenopus oocytes expressing NMDA receptors after injection of RNA from rat brain and from cloned subunits of the receptor. Expand
Expression of mRNAs Encoding Subunits of the NMDA Receptor in Developing Rat Brain
TLDR
The results show that the expression of NR1 splice variants and NR2 subunits is differentially regulated in various brain regions during development, which is likely to underlie some of the changes in the functional and pharmacological properties of NMDA receptors that occur during development. Expand
Sensitivity of the N-methyl-D-aspartate receptor to polyamines is controlled by NR2 subunits.
TLDR
Stimulation, seen in the presence of physiological concentrations of Ca2+ and Mg2+, may be the predominant effect of polyamines at NMDA receptors in the intact nervous system. Expand
Targeting acute ischemic stroke with a calcium-sensitive opener of maxi-K potassium channels
TLDR
The novel fluoro-oxindoles BMS-204352 and racemic compound 1 are potent, effective and uniquely Ca++-sensitive openers of maxi-K channels, thereby augmenting an endogenous mechanism for regulating Ca++ entry and membrane potential. Expand
Modulation of the NMDA receptor by polyamines.
TLDR
Endogenous polyamines may modulate excitatory synaptic transmission by acting at the polyamine recognition site of the NMDA receptor, which could represent a novel therapeutic target for the treatment of ischemia-induced neurotoxicity, epilepsy, and neurodegenerative diseases. Expand
Biochemistry of catecholamines.
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