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Culture matrix configuration and composition in the maintenance of hepatocyte polarity and function.
Several extracellular matrix (ECM) configurations involving type I collagen and Matrigel were examined for their ability to support differentiated function and polarity of cultured adult ratExpand
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Cytoskeleton-based forecasting of stem cell lineage fates
Stem cells that adopt distinct lineages cannot be distinguished based on traditional cell shape. This study reports that higher-order variations in cell shape and cytoskeletal organization that occurExpand
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Effect of extracellular matrix topology on cell structure, function, and physiological responsiveness: hepatocytes cultured in a sandwich configuration
Extracellular matrix (ECM) geometry is an important modulator of cell polarity and function. For example, 3‐dimensional matrices often more effectively induce differentiated cell function thanExpand
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Mechanochemical manipulation of hepatocyte aggregation can selectively induce or repress liver-specific function.
Controlled activation of hepatocyte aggregation is critical to three-dimensional (3D) multicellular morphogenesis during native regeneration of liver as well as tissue reconstruction therapies. InExpand
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Tartaric acid-based amphiphilic macromolecules with ether linkages exhibit enhanced repression of oxidized low density lipoprotein uptake.
Cardiovascular disease initiates with the atherogenic cascade of scavenger receptor- (SR-) mediated oxidized low-density lipoprotein (oxLDL) uptake. Resulting foam cell formation leads to lipid-richExpand
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PEG-variant biomaterials as selectively adhesive protein templates: model surfaces for controlled cell adhesion and migration.
Our study focused on the role of poly(ethylene glycol) (PEG) in actively regulating the biological responsiveness of protein-adsorbed biomaterials. To this end, we designed PEG-variant biomaterialsExpand
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Engineering hepatocellular morphogenesis and function via ligand-presenting hydrogels with graded mechanical compliance.
In order to evaluate the sensitivity of hepatocellular cultures to variations in both substrate stiffness and bioactive ligand presentation, hepatocytes were cultured on differentially compliantExpand
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Generation and transplantation of reprogrammed human neurons in the brain using 3D microtopographic scaffolds
Cell replacement therapy with human pluripotent stem cell-derived neurons has the potential to ameliorate neurodegenerative dysfunction and central nervous system injuries, but reprogrammed neuronsExpand
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Micellar and structural stability of nanoscale amphiphilic polymers: Implications for anti-atherosclerotic bioactivity.
Atherosclerosis, a leading cause of mortality in developed countries, is characterized by the buildup of oxidized low-density lipoprotein (oxLDL) within the vascular intima, unregulated oxLDL uptakeExpand
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Synthesis and Cytotoxicity of Y2O3 Nanoparticles of Various Morphologies
As the field of nanotechnology continues to grow, evaluating the cytotoxicity of nanoparticles is important in furthering their application within biomedicine. Here, we report the synthesis,Expand
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