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MiR423-5p As a Circulating Biomarker for Heart Failure
Rationale: Aberrant expression profiles of circulating microRNAs (miRNAs) have been described in various diseases and provide high sensitivity and specificity. We explored circulating miRNAs asExpand
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Large Expression Differences in Genes for Iron and Zinc Homeostasis, Stress Response, and Lignin Biosynthesis Distinguish Roots of Arabidopsis thaliana and the Related Metal Hyperaccumulator Thlaspi
The micronutrient zinc has an essential role in physiological and metabolic processes in plants as a cofactor or structural element in 300 catalytic and noncatalytic proteins, but it is very toxicExpand
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Mechanisms of Age-Dependent Response to Winter Temperature in Perennial Flowering of Arabis alpina
Multiple Inputs to Flowering Perennial plants need to cycle through an extended vegetative phase, in a process known as vernalization, before they initiate flowering. Bergonzi et al. (p. 1094) andExpand
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Expression differences for genes involved in lignin, glutathione and sulphate metabolism in response to cadmium in Arabidopsis thaliana and the related Zn/Cd-hyperaccumulator Thlaspi caerulescens.
Cadmium (Cd) is a widespread, naturally occurring element present in soil, rock, water, plants and animals. Cd is a non-essential element for plants and is toxic at higher concentrations. TranscriptExpand
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Critical assessment of human metabolic pathway databases: a stepping stone for future integration
TLDR
We compared the genes, EC numbers and reactions of five frequently used metabolic pathway databases. Expand
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Platelets in Patients with Premature Coronary Artery Disease Exhibit Upregulation of miRNA340* and miRNA624*
Background Coronary artery disease (CAD) is the leading cause of human morbidity and mortality worldwide, underscoring the need to improve diagnostic strategies. Platelets play a major role, not onlyExpand
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Trigger-happy resident memory CD4+ T cells inhabit the human lungs
Resident memory T cells (TRM) reside in the lung epithelium and mediate protective immunity against respiratory pathogens. Although lung CD8+ TRM have been extensively characterized, the propertiesExpand
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Notch controls the magnitude of T helper cell responses by promoting cellular longevity
Generation of effective immune responses requires expansion of rare antigen-specific CD4+ T cells. The magnitude of the responding population is ultimately determined by proliferation and survival.Expand
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A comparison of mixture models for density estimation
Gaussian mixture models (GMMs) are a popular tool for density estimation. However, these models are limited by the fact that they either impose strong constraints on the covariance matrices of theExpand
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Multi-omic data analysis using Galaxy
[Extract] Comprehensive multi-omic data acquisition has become a reality, largely driven by the availability of high-throughput sequencing technologies for genomes and transcriptomes1, andExpand
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