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Anti‐Inflammatory and Anticancer Activity of Ergoflavin Isolated from an Endophytic Fungus
Egoflavin, a pigment from an endophytic fungus growing on the leaves of an Indian medicinal plant Mimosops elengi (bakul), is isolated and showed good anti-inflammatory and anticancer activities. Expand
Quinomycin A targets Notch signaling pathway in pancreatic cancer stem cells
Clinical data suggest that Quinomycin is a potent inhibitor of pancreatic cancer that targets the stem cells by inhibiting Notch signaling proteins. Expand
Dysoxylum binectariferum Hook.f (Meliaceae), a rich source of rohitukine.
Rohitukine, a chromane alkaloid, is a precursor of flavopiridol, a promising anti-cancer compound. Currently in Phase III clinical trials, flavopiridol is a potent inhibitor of severalExpand
Antibacterial Activity of 2-(2′,4′-Dibromophenoxy)-4,6-dibromophenol from Dysidea granulosa
2-(2′,4′-Dibromophenoxy)-4,6-dibromophenol isolated from the marine sponge Dysidea granulosa (Bergquist) collected off the coast of Lakshadweep islands, Indian Ocean, exhibited potent and broadExpand
In Vitro and In Vivo Activities of Antibiotic PM181104
In vitro and in vivo studies of a novel thiazolyl cyclic-peptide antibiotic, PM181104, which exhibited a potent in vitro antibacterial activity against a broad range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Expand
Anticancer activity of sclerotiorin, isolated from an endophytic fungus Cephalotheca faveolata Yaguchi, Nishim. & Udagawa.
Sclerotiorin was found to be potent anti-proliferative against different cancer cells and to induce apoptosis in colon cancer cells through the activation of BAX, and down-regulation of BCL-2, those further activated cleaved caspase-3 causing apoptosis of cancer cells. Expand
Fermentation, Isolation, Structure, and antidiabetic activity of NFAT-133 produced by Streptomyces strain PM0324667
Investigations revealed the antidiabetic potential of NFAT-133 which is a potential lead compound which can be considered for development as a therapeutic for the treatment of type-2 diabetes. Expand
Anticancer activity of new depsipeptide compound isolated from an endophytic fungus
A novel depsipeptide was purified from an endophytic fungus Phomopsis glabrae isolated from the leaves of Pongamia pinnata and exhibited in vitro anticancer activity against 40 human cancer cell lines and ex vivo efficacy towards 24 human tumor xenografts. Expand
In Vitro and In Vivo Activities of Antibiotic PM 181104
The drug resistance has become a global threat and if not addressed we may enter in pre-antibiotic era. A way to overcome growing incidence of global antibiotic resistance issue is to introduceExpand
Saussurea heteromalla (D. Don) Hand.-Mazz.: A new source of arctiin, arctigenin and chlorojanerin
Saussurea heteromalla (D. Don) Hand.-Mazz. (Asteraceae), a Himalayan herb, has been investigated phytochemically for the first time in detail and the plant is being reported here as a new source ofExpand