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Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.
A critical role is demonstrated for Nkx2.1 in morphogenesis of the anterior foregut and the lung as well as in differentiation of pulmonary epithelial cells.
Wnt5a participates in distal lung morphogenesis.
It is shown that Wnt5a is expressed in the mouse lung and plays an important role in lung distal morphogenesis and the overall architecture of the mutant lungs is characterized by overexpansion of the distal airways and inhibition of lung maturation as reflected by persistence of thickened intersaccular interstitium.
The Human Tim/Tipin Complex Coordinates an Intra-S Checkpoint Response to UV That Slows Replication Fork Displacement
- Keziban Ünsal-Kaçmaz, P. Chastain, W. Kaufmann
- Biology, ChemistryMolecular and Cellular Biology
- 12 February 2007
Findings indicate that the Tim-Tipin complex mediates the UV-induced intra-S checkpoint, Tim is needed to maintain DNA replication fork movement in the absence of damage, Tipin interacts with RPA on DNA and, in UV-damaged cells,tipin slows DNA chain elongation in active replicons.
Localized Fgf10 expression is not required for lung branching morphogenesis but prevents differentiation of epithelial progenitors
- Thomas Volckaert, A. Campbell, E. Dill, Changgong Li, P. Minoo, S. D. De Langhe
- 15 September 2013
Interestingly, the data presented here show that once epithelial cells are committed to the Sox2-positive airway epithelial cell fate, Fgf10 prevents ciliated cell differentiation and promotes basal cell differentiation, which supports a model in which the main function of F gf10 during lung development is to regulate proximal-distal differentiation.
Interactions Between β-Catenin and Transforming Growth Factor-β Signaling Pathways Mediate Epithelial-Mesenchymal Transition and Are Dependent on the Transcriptional Co-activator cAMP-response…
TGF-β induction of α-smooth muscle actin (α-SMA) involves ternary complex formation among Smad3, β-catenin, and CBP, which suggests a new therapeutic approach to pulmonary fibrosis by specifically uncoupling CBP/ catenin-dependent signaling downstream of TGF- β.
Undetectable Interleukin (IL)-10 and Persistent IL-8 Expression Early in Hyaline Membrane Disease: A Possible Developmental Basis for the Predisposition to Chronic Lung Inflammation in Preterm…
It is demonstrated that IL-10 mRNA and protein expression by lung inflammatory cells is related to gestational age and during the first 96 h of life neutrophil cell counts and IL-8 expression decrease in BAL from term infants, but remain unchanged in BAL samples from preterm infants.
Wnt5a regulates Shh and Fgf10 signaling during lung development.
Fgf10 dosage is critical for the amplification of epithelial cell progenitors and for the formation of multiple mesenchymal lineages during lung development.
Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2
It is reported that Ror2 also positively modulates Wnt3a-activated canonical signaling in a lung carcinoma, H441 cell line and these findings support a functional scheme whereby regulation of Wnt signaling is achieved by cooperative functions of multiple mediators.
Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein.
- Qian Zhong, B. Zhou, Z. Borok
- Biology, MedicineAmerican journal of respiratory cell and…
- 1 September 2011
It is demonstrated that ER stress induces EMT in AECs, at least in part through Src-dependent pathways, suggesting a novel role for ER stress in fibroblast accumulation in pulmonary fibrosis.