• Publications
  • Influence
Subcellular localization of the yeast proteome.
Protein localization data are a valuable information resource helpful in elucidating eukaryotic protein function. Here, we report the first proteome-scale analysis of protein localization within anyExpand
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Twenty years of ModelDB and beyond: building essential modeling tools for the future of neuroscience
TLDR
Neuron modeling may be said to have originated with the Hodgkin and Huxley action potential model in 1952 and Rall’s models of integrative activity of dendrites in 1964. Expand
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Large-scale analysis of the yeast genome by transposon tagging and gene disruption
Economical methods by which gene function may be analysed on a genomic scale are relatively scarce. To fill this need, we have developed a transposon-tagging strategy for the genome-wide analysis ofExpand
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X!!Tandem, an improved method for running X!tandem in parallel on collections of commodity computers.
TLDR
The widespread use of mass spectrometry for protein identification has created a demand for computationally efficient methods of matching mass Spectrometry data to protein databases. A search using X!Tandem, a popular and representative program, can require hours or days to complete, particularly when missed cleavages and post-translational modifications are considered. Expand
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Application of Information Technology: Organization of Heterogeneous Scientific Data Using the EAV/CR Representation
TLDR
Entity-attribute-value (EAV) representation is a means of organizing highly heterogeneous data using a relatively simple physical database schema. Expand
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ALFRED: the ALelle FREquency Database. Update
Elaboration of ALFRED (http://alfred.med.yale.edu) is being continued in two directions. One of which is developing tools for efficiently annotating the entries and checking the integrity of the dataExpand
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The Neuroscience Information Framework: A Data and Knowledge Environment for Neuroscience
TLDR
With support from the Institutes and Centers forming the NIH Blueprint for Neuroscience Research, we have designed and implemented a new initiative for integrating access to and use of Web-based neuroscience resources. Expand
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Research Paper: Exploring Performance Issues for a Clinical Database Organized Using an Entity-Attribute-Value Representation
TLDR
We performed a pilot study that systematically quantifies performance differences for database queries directed at real-world microbiology data modeled with EAV/CR and conventional representations, and to explore the relative merits of different query implementation strategies. Expand
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An integrated approach for finding overlooked genes in yeast
We report here the discovery of 137 previously unappreciated genes in yeast through a widely applicable and highly scalable approach integrating methods of gene-trapping, microarray-based expressionExpand
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ALFRED: an allele frequency database for diverse populations and DNA polymorphisms
TLDR
We have developed a publicly accessible database (ALFRED, the ALlele FREquency Database) that catalogues allele frequency data for a wide range of population samples and DNA polymorphisms. Expand
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