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Time-dependent changes in alcohol-seeking behaviour during abstinence
Alcohol-seeking behaviour may become more intense after long-term imposed abstinence and alcohol self-administration, extinction behaviour, and reinstatement of alcohol- seeking behaviour may be regulated by separate neural mechanisms. Expand
The effects of fatty acid amide hydrolase inhibitors on maintenance of cocaine and food self-administration and on reinstatement of cocaine-seeking and food-taking behavior in rats.
The results indicate that FAAH inhibitors could be potent modulators of motivational and conditioned aspects of goal-directed behaviors with less prominent effects on consumatory behaviors. Expand
Age-dependent lower or higher levels of hair mercury in autistic children than in healthy controls.
The results suggest that autistic children differ from healthy children in metabolism of mercury, which seems to change with age. Expand
GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators
A wealth of data now supports the benefits of GABAB receptor PAMs and clinical validation is now warranted, given that anxiolytic effects are reported with such ligands they may also benefit in mitigating the withdrawal from drugs of abuse. Expand
Novel multi-target-directed ligands for Alzheimer's disease: Combining cholinesterase inhibitors and 5-HT6 receptor antagonists. Design, synthesis and biological evaluation.
A novel class of multifunctional ligands with compound 12 as the best derivative in a series represents an excellent starting point for the further development of an effective treatment for AD. Expand
Rapid and Robust Protection against Cocaine-Induced Lethality in Rats by the Bacterial Cocaine Esterase
Preliminary evidence is provided that the enzyme CocE could serve as a suitable antidote to cocaine toxicity in humans by assessing its ability to prevent cocaine-induced convulsions and lethality in the rat. Expand
Marked elevation of adrenal steroids, especially androgens, in saliva of prepubertal autistic children
Salivary levels of selected steroids may serve as biomarkers of autism pathology useful for monitoring the progress of therapy, and are suggested to be more prominent in older autistic children and in boys. Expand
Intravenous self-administration of morphine and cocaine: a comparative study.
The aim of the present study was to estimate differences between patterns of morphine and cocaine use in Sprague-Dawley rats. This was done by first developing a set of conditions under which bothExpand
Post-session injections of a protein synthesis inhibitor, cycloheximide do not alter saccharin self-administration
The present results suggest that well-consolidated long-term memory of an appetitive instrumental task does not depend on de novo protein synthesis. Expand
Acoustic startle responses and prepulse inhibition of acoustic startle responses in Warsaw alcohol high-preferring (WHP) and Warsaw alcohol low-preferring (WLP) rats.
The results of the present study suggest that exaggerated startle responses can be a physiological/behavioral marker of a propensity to abuse alcohol. Expand