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Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro.
TLDR
It is reported here that HCVcc strain FL-J6/JFH can establish long-term infections in chimpanzees and in mice containing human liver grafts, and virus recovered from these animals was highly infectious in cell culture, demonstrating efficient ex vivo culture of HCV.
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Cell Culture Adaptation of Hepatitis C Virus and In Vivo Viability of an Adapted Variant
TLDR
The generation of cell culture-adapted JFH1 variants yielding higher titers of infectious particles and enhanced spread of infection in cultured cells is described and results argue for some level of impaired fitness of this mutant in vivo.
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Anti‐CD81 antibodies can prevent a hepatitis C virus infection in vivo
TLDR
It is shown that CD81 is indispensable for an authentic in vivo HCV infection, and new perspectives for the prevention of allograft reinfection after orthotopic liver transplantation in chronically infected HCV patients are opened.
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Griffithsin Has Antiviral Activity against Hepatitis C Virus
TLDR
A novel strategy to prevent HCV infection using a lectin, griffithsin (GRFT) that specifically binds N-linked high-mannose oligosaccharides that are present on the viral envelope is evaluated.
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Scavenger Receptor BI and BII Expression Levels Modulate Hepatitis C Virus Infectivity
TLDR
It is demonstrated that HCV soluble E2 can interact with human SR- BI and SR-BII, and anti-SR-BI antibodies inhibited the infectivity of cell culture- and plasma-derived J6/JFH, suggesting a critical role for SR-bi/II in HCV infection.
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Role of the Hepatitis C Virus Core+1 Open Reading Frame and Core cis-Acting RNA Elements in Viral RNA Translation and Replication
TLDR
SL47 and SL87 are important RNA elements contributing to HCV genome translation and robust replication in cell culture and in vivo, and they are detrimental for virus viability.
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Morphological and biochemical characterization of a human liver in a uPA‐SCID mouse chimera
TLDR
The repopulation, organization, and function of human hepatocytes in a mouse recipient and the infections with hepatitis B virus (HBV) and hepatitis C virus (HCV) of the transplanted cells are described.
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Polyphenols Inhibit Hepatitis C Virus Entry by a New Mechanism of Action
TLDR
EGCG and delphinidin inhibit HCV entry by a new mechanism, i.e., alteration of the viral particle structure that impairs its attachment to the cell surface, inducing a bulge on the viral envelope.
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Characterization of a novel monoclonal antibody targeting epitope II within hepatitis C virus E2 envelope glycoprotein
TLDR
MAb2A5 shows potent anti-HCV neutralizing activity and could hence provide an effective strategy to prevent HCV recurrence in chronically infected HCV LT-patients and can be applied for the design of prophylactic HCV vaccines with cross-protection activity.
The human liver-uPA-SCID mouse: a model for the evaluation of antiviral compounds against HBV and HCV.
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