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Timing and checkpoints in the regulation of mitotic progression.
Accurate chromosome segregation relies on the precise regulation of mitotic progression. Regulation involves control over the timing of mitosis and a spindle assembly checkpoint that links anaphaseExpand
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Human TPX2 is required for targeting Aurora-A kinase to the spindle
Aurora-A is a serine-threonine kinase implicated in the assembly and maintenance of the mitotic spindle. Here we show that human Aurora-A binds to TPX2, a prominent component of the spindleExpand
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Aurora‐A overexpression reveals tetraploidization as a major route to centrosome amplification in p53−/− cells
Aberrations in centrosome numbers have long been implicated in aneuploidy and tumorigenesis, but their origins are unknown. Here we have examined how overexpression of Aurora‐A kinase causesExpand
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Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin A
Centrosome duplication is a key requirement for bipolar spindle formation and correct segregation of chromosomes during cell division. In a manner highly reminiscent of DNA replication, theExpand
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C-Nap1, a Novel Centrosomal Coiled-Coil Protein and Candidate Substrate of the Cell Cycle–regulated Protein Kinase Nek2
Nek2 (for NIMA-related kinase 2) is a mammalian cell cycle–regulated kinase structurally related to the mitotic regulator NIMA of Aspergillus nidulans. In human cells, Nek2 associates withExpand
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A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators
Nek2, a mammalian protein kinase of unknown function, is closely related to the mitotic regulator NIMA of Aspergillus nidulans. Here we show by both immunofluorescence microscopy and biochemicalExpand
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Phylogenetic and structural analysis of centromeric DNA and kinetochore proteins
BackgroundKinetochores are large multi-protein structures that assemble on centromeric DNA (CEN DNA) and mediate the binding of chromosomes to microtubules. Comprising 125 base-pairs of CEN DNA andExpand
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Polo-like kinase 1 regulates Nlp, a centrosome protein involved in microtubule nucleation.
In animal cells, most microtubules are nucleated at centrosomes. At the onset of mitosis, centrosomes undergo a structural reorganization, termed maturation, which leads to increased microtubuleExpand
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Bub1 regulates chromosome segregation in a kinetochore-independent manner
The kinetochore-bound protein kinase Bub1 performs two crucial functions during mitosis: it is essential for spindle checkpoint signaling and for correct chromosome alignment. Interestingly, Bub1Expand
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A dual role for Bub1 in the spindle checkpoint and chromosome congression
The spindle checkpoint ensures faithful chromosome segregation by linking the onset of anaphase to the establishment of bipolar kinetochore–microtubule attachment. The checkpoint is mediated by aExpand
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