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Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction.
- P. Menasché, A. Hagege, +11 authors D. Duboc
- Journal of the American College of Cardiology
- 2 April 2003
OBJECTIVES This phase I trial was designed to assess the feasibility and safety of autologous skeletal myoblast transplantation in patients with severe ischemic cardiomyopathy. BACKGROUND… Expand
Myoblast transplantation for heart failure
Intramyocardial skeletal muscle transplantation has been shown experimentally to improve heart function after infarction. We report success with this procedure in a patient with severe ischaemic… Expand
The Myoblast Autologous Grafting in Ischemic Cardiomyopathy (MAGIC) Trial: First Randomized Placebo-Controlled Study of Myoblast Transplantation
Background— Phase I clinical studies have demonstrated the feasibility of implanting autologous skeletal myoblasts in postinfarction scars. However, they have failed to determine whether this… Expand
A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates.
- G. Blin, David Nury, +18 authors M. Pucéat
- Medicine, Biology
- The Journal of clinical investigation
- 1 April 2010
Cell therapy holds promise for tissue regeneration, including in individuals with advanced heart failure. However, treatment of heart disease with bone marrow cells and skeletal muscle progenitors… Expand
Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study.
BACKGROUND The EXPEDITION study addressed the efficacy and safety of inhibiting the sodium hydrogen exchanger isoform-1 (NHE-1) by cariporide in the prevention of death or myocardial infarction (MI)… Expand
Human embryonic stem cell-derived cardiac progenitors for severe heart failure treatment: first clinical case report.
AIMS Comparative studies suggest that stem cells committed to a cardiac lineage are more effective for improving heart function than those featuring an extra-cardiac phenotype. We have therefore… Expand
Cell-based cardiac repair: reflections at the 10-year point.
Received February 28, 2005; revision received April 25, 2005; accepted April 29, 2005. It has now been more than a decade since the first experiments were performed using cell transplantation for… Expand
Experimental evaluation of Celsior, a new heart preservation solution.
- P. Menasché, J. Termignon, +6 authors G. Bloch
- European journal of cardio-thoracic surgery…
An original heart preservation solution (Celsior) has been developed, the formulation of which has been designed to fulfil two major objectives: (1) to combine the general principles of hypothermic… Expand
Myoblasts transplanted into rat infarcted myocardium are functionally isolated from their host
- B. Leobon, I. Garcin, P. Menasché, J. Vilquin, E. Audinat, S. Charpak
- Biology, Medicine
- Proceedings of the National Academy of Sciences…
- 12 June 2003
Survival and differentiation of myogenic cells grafted into infarcted myocardium have raised the hope that cell transplantation becomes a new therapy for cardiovascular diseases. The approach was… Expand
Skeletal myoblasts and cardiac repair.
- P. Menasché
- Journal of molecular and cellular cardiology
- 1 October 2008
The seminal experiments showing that cells transplanted in infarcted hearts could effect myocardial tissue repair have provided the proof of concept that cell therapy might be an effective means of… Expand