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Spatial distribution of triazine residues in a shallow alluvial aquifer linked to groundwater residence time
Increasing triazine concentrations with depth is consistent with a significant decrease in the use of these pesticides for the last 10 years on this area and highlights the efficiency of their ban. Expand
The Rational Design, Synthesis, and Antimicrobial Properties of Thiophene Derivatives That Inhibit Bacterial Histidine Kinases.
A structure-based drug design strategy that begins from an inhibitor-bound crystal structure and includes a significant number of structurally simplifiying "intuitive" modifications to arrive at the simple achiral, biaryl target structures is used. Expand
A concise synthesis of l-4,4-difluoroglutamine
Abstract l -4,4-Difluoroglutamine 1 of high optical purity was prepared from ( R )-Garner's aldehyde 2 using Reformatsky reaction as the key step for introducing the fluorinated side-chain.
Practical one-step synthesis of ethynylglycine synthon from Garner's aldehyde
A simple, efficient and practical synthesis of (R)-2,2-dimethyl-3-(tert-butoxycarbonyl)-4-ethynyloxazolidine (ethynylglycine synthon) is described. The method involves in situ formation of dimethylExpand
Synthesis of 1,4-disubstituted 1,2,3-triazole Derivatives Using Click Chemistry and their Src Kinase Activities.
Results from the design and synthesis of a series of 1,4-disubstituted 1,2,3-triazoles derivatives are significant evidence to demonstrate the compound 3m could be optimized as a potential Src kinase inhibitor in further studies. Expand
Synthesis of optically active β,γ-alkynylglycine derivatives
Abstract Full results on the first synthesis of optically active β,γ-alkynylglycine derivatives from naturally occurring L-serine are described. The methodology uses L-serinal as a key intermediateExpand
γ-Fluorinated analogues of glutamic acid and glutamine
Summary. γ-Fluorinated analogues of glutamic acid and glutamine are compounds of biological interest. Syntheses of such compounds are extensively reviewed in this article. 4-Fluoroglutamic acid wasExpand
A Straightforward Synthesis of N-Boc-L-serinal and N-Boc-L-threoninal Acetonides
Abstract An improved procedure for the synthesis of optically active N-tert-butoxycarbonyl L-serinal acetonide and threoninal analogue from ester precursors is described.
β,γ-Alkynylα-amino acids: a synthetic challenge
This review focuses on racemic syntheses of ethynyl glycine and otherβ,γ-alkynylα-amino acid derivatives, including patent data, and details the only satisfactory strategy that has led to optically activeβ, α-aminos acids derivatives up to now. Expand