Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
In addition to the APOE locus (encoding apolipoprotein E), 19 loci reached genome-wide significance (P < 5 × 10−8) in the combined stage 1 and stage 2 analysis, of which 11 are newly associated with Alzheimer's disease.
Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
A large genome-wide association meta-analysis of clinically diagnosed late-onset Alzheimer’s disease (LOAD) from 94,437 individuals identifies new LOAD risk loci and implicates Aβ formation, tau protein binding, immune response and lipid metabolism.
Alzheimer's disease: clinical trials and drug development
Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
Results confirm that mitochondrial DNA is particularly sensitive to oxidative damage, and they show that there is increased oxidative damage to DNA in AD, which may contribute to the neurodegenerative process.
Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review
IADL requiring higher neuropsychological functioning seem to be most severely affected in patients with MCI, and the development of performance-based assessment instruments should be intensified, as they allow a valid and reliable assessment of subtle IADL deficits in MCI.
Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.
Validation of the Five‐Item Geriatric Depression Scale in Elderly Subjects in Three Different Settings
- P. Rinaldi, P. Mecocci, A. Cherubini
- Medicine, EducationJournal of The American Geriatrics Society
- 1 May 2003
A five‐item version of the Geriatric Depression Scale (GDS) for the screening of depression in community‐dwelling older subjects, hospitalized older patients, and nursing home residents is tested.
Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain
Results show for the first time that there is a progressive age‐related accumulation in oxidative damage to DNA in human brain, and that the mtDNA is preferentially affected and it is possible that such damage may contribute to age‐dependent increases in incidence of neurodegenerative diseases.
Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.
- D. Maggio, M. Barabani, A. Cherubini
- MedicineJournal of Clinical Endocrinology and Metabolism
- 1 April 2003
The results reveal that antioxidant defenses are markedly decreased in osteoporotic women, and the mechanisms underlying antioxidant depletion and its relevance to the pathogenesis of osteoporeosis deserve further investigation.