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Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Eleven susceptibility loci for late-onset Alzheimer's disease (LOAD) were identified by previous studies; however, a large portion of the genetic risk for this disease remains unexplained. WeExpand
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Alzheimer's disease: clinical trials and drug development
Alzheimer's disease is the most common cause of dementia in elderly people. Research into Alzheimer's disease therapy has been at least partly successful in terms of developing symptomaticExpand
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Oxidative damage to mitochondrial DNA is increased in Alzheimer's disease
Oxidative damage to DNA may play a role in both normal aging and in neurodegenerative diseases. We examined whether Alzheimer's disease (AD) is associated with increased oxidative damage to both nDNAExpand
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Oxidative stress in brain aging, neurodegenerative and vascular diseases: an overview.
According to the free radical theory, aging can be considered as a progressive, inevitable process partially related to the accumulation of oxidative damage into biomolecules -- nucleic acids,Expand
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Mild cognitive impairment and deficits in instrumental activities of daily living: a systematic review
IntroductionThere is a growing body of evidence that subtle deficits in instrumental activities of daily living (IADL) may be present in mild cognitive impairment (MCI). However, it is not clear ifExpand
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Oxidative damage to mitochondrial DNA shows marked age‐dependent increases in human brain
A major theory of aging is that oxidative damage may accumulate in DNA and contribute to physiological changes associated with aging. We examined age‐related accumulation of oxidative damage to bothExpand
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Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study.
Although recent epidemiological studies found a positive correlation between dietary vitamin C intake and bone mineral density, data on plasma levels of vitamin C or other antioxidants inExpand
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Validation of the Five‐Item Geriatric Depression Scale in Elderly Subjects in Three Different Settings
OBJECTIVES: To test the effectiveness of a five‐item version of the Geriatric Depression Scale (GDS) for the screening of depression in community‐dwelling older subjects, hospitalized older patients,Expand
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Plasma antioxidants are similarly depleted in mild cognitive impairment and in Alzheimer’s disease
In order to assess peripheral levels and activities of a broad spectrum of non-enzymatic and enzymatic antioxidants in elderly subjects with mild cognitive impairment (MCI) and Alzheimer's diseaseExpand
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Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease.
CONTEXT Blood-based analytes may be indicators of pathological processes in Alzheimer disease (AD). OBJECTIVE To identify plasma proteins associated with AD pathology using a combined proteomic andExpand
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