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Identification of programmed cell death (apoptosis) in situ by means of specific labeling of nuclear DNA fragments in heart biopsy samples during acute rejection episodes.
BACKGROUND AND METHODS In sixty-three endomyocardial biopsy samples collected from six heart transplant recipients for the diagnosis of acute rejection episodes, the presence of apoptosis inExpand
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Inhibitory Receptors Are Expressed by Trypanosoma cruzi-Specific Effector T Cells and in Hearts of Subjects with Chronic Chagas Disease
We had formerly demonstrated that subjects chronically infected with Trypanosoma cruzi show impaired T cell responses closely linked with a process of T cell exhaustion. Recently, the expression ofExpand
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Effect of chagasic sera on the rat isolated atrial preparation: immunological, morphological and function aspects.
An antibody reacting with the plasma membrane of working myocardial cells, skeletal muscle fibres, and endothelial cells (EVI antibody) has been described in the sera of patients with Chagas'Expand
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Endomitosis and polyploidization of myocardial cells in the periphery of human acute myocardial infarction.
OBJECTIVE Although the genetic program for reinitiating DNA synthesis exists in post-mitotic cardiomyocytes, and it was reported that in human acute myocardial infarction (AMI) a significantExpand
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Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep
We have recently reported that in pigs with chronic myocardial ischemia heart transfection with a plasmid encoding the 165 isoform of human vascular endothelial growth factor (pVEGF165) induces anExpand
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Arteriogenesis induced by intramyocardial vascular endothelial growth factor 165 gene transfer in chronically ischemic pigs.
Exogenous vascular endothelial growth factor (VEGF) improves tissue perfusion in large animals and humans with chronic myocardial ischemia. Because tissue perfusion is mainly dependent on theExpand
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Junin virus infection of guinea pigs: immunohistochemical and ultrastructural studies of hemopoietic tissue.
An association between viral antigens, cytopathic effect (CPE) and viral titers in blood and lymphoid tissues suggests a direct CPE of Junin virus on the lymphopoietic organs of guinea pigs infectedExpand
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Cardiac myocyte nuclear size and ploidy status decrease after mechanical support.
Two patients with end-stage dilated cardiomyopathy of ischemic and idiopathic origin were treated with a left ventricular assist device (LVAD) as a bridge for heart transplantation. Myocardial tissueExpand
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Role of macrophage inflammatory protein-1α (MIP-1α) in macrophage homing in the spleen and heart pathology during experimental infection with Trypanosoma cruzi
Abstract We investigated in vivo the effect of macrophage inflammatory protein-1α (MIP-1α) inhibition upon the cellular recruitment into tissue damage sites and spleen histology in mice acutelyExpand
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