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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
There is increasing evidence that genome-wide association (GWA) studies represent a powerful approach to the identification of genes involved in common human diseases. We describe a joint GWA studyExpand
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A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system.
• An operational criteria checklist for psychotic illness and computer programs designed to be used in conjunction with it constitute the OPCRIT system. This provides a simple and reliable method ofExpand
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Gene–environment interaction analysis of serotonin system markers with adolescent depression
We report analyses from a study of gene–environment interaction in adolescent depression. The sample was selected from 1990 adolescents aged 10–20 years: those with depression symptoms in the top orExpand
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The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studiesExpand
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Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
To identify susceptibility loci for bipolar disorder, we tested 1.8 million variants in 4,387 cases and 6,209 controls and identified a region of strong association (rs10994336, P = 9.1 × 10−9) inExpand
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The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
Gene–environmental interaction (G × E) between a common functional polymorphism in the promoter region of the serotonin transporter gene (5-HTT) and environmental adversity on the onset of depressionExpand
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Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
Major depressive disorder (MDD) is a common illness accompanied by considerable morbidity, mortality, costs, and heightened risk of suicide. We conducted a genome-wide association meta-analysis basedExpand
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Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Most psychiatric disorders are moderately to highly heritable. The degree to which genetic variation is unique to individual disorders or shared across disorders is unclear. To examine shared geneticExpand
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The heritability of bipolar affective disorder and the genetic relationship to unipolar depression.
BACKGROUND Twin studies of bipolar affective disorder (BPD) have either been small or have not used explicit diagnostic criteria. There has been little use of genetic model fitting and no analyses toExpand
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Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
We have genotyped 14,436 nonsynonymous SNPs (nsSNPs) and 897 major histocompatibility complex (MHC) tag SNPs from 1,000 independent cases of ankylosing spondylitis (AS), autoimmune thyroid diseaseExpand
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