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Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
This study has demonstrated that careful use of a shared control group represents a safe and effective approach to GWA analyses of multiple disease phenotypes; generated a genome-wide genotype database for future studies of common diseases in the British population; and shown that, provided individuals with non-European ancestry are excluded, the extent of population stratification in theBritish population is generally modest. Expand
A polydiagnostic application of operational criteria in studies of psychotic illness. Development and reliability of the OPCRIT system.
• An operational criteria checklist for psychotic illness and computer programs designed to be used in conjunction with it constitute the OPCRIT system. This provides a simple and reliable method ofExpand
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder
The results suggest that ion channelopathies may be involved in the pathogenesis of bipolar disorder and found further support for the previously reported CACNA1C. Expand
The heritability of bipolar affective disorder and the genetic relationship to unipolar depression.
There are substantial genetic and nonshared environmental correlations between mania and depression, but most of the genetic variance in liability to mania is specific to the manic syndrome. Expand
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression
A genome-wide association meta-analysis of individuals with clinically assessed or self-reported depression identifies 44 independent and significant loci and finds important relationships of genetic risk for major depression with educational attainment, body mass, and schizophrenia. Expand
The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis
While the G × E has been consistently detected in young adult samples, there are contradictory findings in adolescent boys and elderly people and the method of assessment of environmental adversity is also important with detailed interview-based approaches being associated with positive G ×E findings. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
The analysis of 51 genes in DSM-IV combined type attention deficit hyperactivity disorder: association signals in DRD4, DAT1 and 16 other genes
Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder, starting in early childhood and persisting into adulthood in the majority of cases. Family and twin studiesExpand
Association scan of 14,500 nonsynonymous SNPs in four diseases identifies autoimmunity variants
These findings, enabled in part by increased statistical power resulting from the expansion of the control reference group to include individuals from the other disease groups, highlight notable new possibilities for autoimmune regulation and suggest that IL23R may be a common susceptibility factor for the major 'seronegative' diseases. Expand
A sib-pair study of the Temperament and Character Inventory scales in major depression.
Harm avoidance, reward dependence, novelty seeking, and self-directedness have traitlike characteristics that are related to the familiality of depression; Cooperativeness, self-transcendence, and persistence are also familial, but this appears to be unrelated to depression. Expand