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The Human Copper-Zinc Superoxide Dismutase Gene (SOD1) Proximal Promoter Is Regulated by Sp1, Egr-1, and WT1 via Non-canonical Binding Sites*
TLDR
It is shown that phorbol 12-myristate 13-acetate (PMA) increases Cu,Zn-SOD mRNA expression within 30 min and the sequence between nucleotides −71 and −29 is essential for both basal and PMA-induced gene expression. Expand
Peptic hydrolysis of gluten, glutenin and gliadin from wheat grain: Kinetics and characterisation of peptides
The kinetics of the hydrolysis of gluten, glutenin and gliadin by pepsin was studied by following the reaction of the hydrolysate with ninhydrin and by SDS-gel electro-phoresis. Glutenin was moreExpand
Pharmacologic and biochemical profiles of new venous antithrombotic beta-D-xyloside derivatives: potential antiathero/thrombotic drugs.
TLDR
In vivo experimentation demonstrated that after treatment by these molecules an important elevation in circulating GAG occurred, with LF 05-0030 presenting the greatest activity, being five times higher than control levels, and dermatan sulfate levels were significantly increased over control values, believed to support the antithrombotic activity observed. Expand
The effect of the beta-D-xyloside naroparcil on circulating plasma glycosaminoglycans. An explanation for its known antithrombotic activity in the rabbit.
TLDR
This is, to the authors' knowledge, the first description of the in vivo effect of a beta-D-xyloside on GAG biosynthesis and this is correlated with an antithrombotic action. Expand
LETTERS TO THE EDITOR: Inhibition of thrombin activatable fibrinolysis inhibitor augments fibrinolysis in human whole blood
TLDR
The effects of the specific TAFIa inhibitor, PCI, on t-PA mediated fibrinolysis using thromboelastography of human whole blood was investigated and showed a dosedependent reduction in MA and increases in Ly30 and Ly60. Expand
Conformational studies of peptides derived by the enzymic hydrolysis of a gamma-type gliadin
The secondary structures of γ 44 gliadin and peptides derived from it by enzymic hydrolysis were studied by circular dichroism spectroscopy. Two peptides, obtained by chymotryptic cleavage, broadlyExpand
Design, Synthesis, and Evaluation of a Novel Series of Indole Sulfonamide Peroxisome Proliferator Activated Receptor (PPAR) α/γ/δ Triple Activators: Discovery of Lanifibranor, a New Antifibrotic
TLDR
Novel indole sulfonamide derivatives that activate the three peroxisome proliferator activated receptor (PPAR) isoforms demonstrated strong activity in models that are relevant to nonalcoholic steatohepatitis (NASH) pathophysiology suggesting therapeutic potential for NASH patients. Expand
Reduction of intimal hyperplasia by naroparcil, a 4-methylumbelliferyl beta-D-xyloside analogue, after arterial injury in the hypercholesterolemic rabbit.
TLDR
In this model, oral treatment with naroparcil appears to preserve the arterial lumen and reduce intimal thickness after arterial injury in the hypercholesterolemic rabbit. Expand
Odiparcil, a potential glycosaminoglycans clearance therapy in mucopolysaccharidosis VI—Evidence from in vitro and in vivo models
TLDR
The data demonstrate that odiparcil effectively diverts the synthesis of cellular glycosaminoglycans into secreted soluble species and this effect can be used for reducing cellular and tissue GAG accumulation in MPS VI models. Expand
Inhibition of Interleukin-23–Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt
TLDR
A novel small molecule inverse agonist of retinoid acid–related orphan receptor (ROR) γt is reported on and its efficacy in preclinical models of psoriasis and arthritis is shown, suggesting small molecules inverse agonists of RORγt could be efficacious in human IL-17–related diseases. Expand
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