• Publications
  • Influence
Microbial Ecology of Dental Plaque and its Significance in Health and Disease
  • P. Marsh
  • Biology, Medicine
    Advances in dental research
  • 1 July 1994
TLDR
It is proposed that disease can be prevented or treated not only by targeting the putative pathogens but also by interfering with the processes that drive the breakdown in homeostasis, and the rate of acid production following sugar intake could be reduced by fluoride, alternative sweeteners, and low concentrations of antimicrobial agents.
Are dental diseases examples of ecological catastrophes?
  • P. Marsh
  • Biology, Medicine
    Microbiology
  • 1 February 2003
Dental diseases are among the most prevalent and costly diseases affecting industrialized societies, and yet are highly preventable. The microflora of dental plaque biofilms from diseased sites is
Dental plaque as a biofilm and a microbial community – implications for health and disease
  • P. Marsh
  • Medicine
    BMC oral health
  • 15 June 2006
TLDR
Arguments will be presented that an appreciation of ecological principles will enable a more holistic approach to be taken in caries control and the suppression of sugar catabolism and acid production by the use of metabolic inhibitors and non-fermentable artificial sweeteners in snacks, or the stimulation of saliva flow, could assist in the maintenance of homeostasis in plaque.
Dental Plaque as a Microbial Biofilm
  • P. Marsh
  • Biology, Medicine
    Caries Research
  • 21 May 2004
TLDR
Oral bacteria in plaque do not exist as independent entities but function as a co-ordinated, spatially organized and fully metabolically integrated microbial community, the properties of which are greater than the sum of the component species.
Oral Microbiology
Dental plaque: biological significance of a biofilm and community life-style.
  • P. Marsh
  • Biology, Medicine
    Journal of clinical periodontology
  • 1 October 2005
TLDR
Dental plaque displays properties that are typical of biofilms and microbial communities in general, a clinical consequence of which is a reduced susceptibility to antimicrobial agents as well as pathogenic synergism.
Extended Survival and Persistence of Campylobacterspp. in Water and Aquatic Biofilms and Their Detection by Immunofluorescent-Antibody and -rRNA Staining
TLDR
In water microcosm experiments, Campylobacter isolates differed by up to twofold, as determined by culturing; this difference increased to fourfold when particular combinations of temperature and oxygenation were used.
Architecture of Intact Natural Human Plaque Biofilms Studied by Confocal Laser Scanning Microscopy
TLDR
An in situ device for the in vivo generation of intact dental plaque biofilms on natural tooth surfaces in human subjects showed a more open architecture, consistent with recent models of biofilm structure from other habitats and has important implications for the delivery of therapeutics to desired targets within the plaque.
The oral microbiome – an update for oral healthcare professionals
TLDR
An update on the current knowledge of the oral microbiome in health and disease is given and implications for modern-day oral healthcare are discussed.
Dental plaque biofilms: communities, conflict and control.
TLDR
Application of novel imaging and molecular techniques has radically altered the understanding of the biology of multi-species biofilms, and key developments that are pertinent to the control of dental plaque are highlighted in this review.
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