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TAZ: a novel transcriptional co‐activator regulated by interactions with 14‐3‐3 and PDZ domain proteins
TAZ may link events at the plasma membrane and cytoskeleton to nuclear transcription in a manner that can be regulated by 14‐3‐3, and is identified as a novel transcriptional co‐activator with PDZ‐binding motif. Expand
Multiple Phosphoinositide 3-Kinase-Dependent Steps in Activation of Protein Kinase B
A mechanism in which 3′ phosphoinositide lipid-dependent translocation of PKB to the plasma membrane promotes serine 473 phosphorylation, which is, in turn, necessary for PDK1-mediatedosphorylation of threonine 308 and, consequentially, full PKB activation is suggested. Expand
LKB1 Associates with Brg1 and Is Necessary for Brg1-induced Growth Arrest*
It is found that L KB1 binds to and regulates brahma-related gene 1 (Brg1), an essential component of chromatin remodeling complexes, and the inability of mutants of LKB1 to mediate Brg1-dependent growth arrest may explain the manifestations of Peutz-Jeghers syndrome. Expand
Vav2 is required for cell spreading
The findings indicate that in fibroblasts Vav2 is necessary for integrin, but not growth factor–dependent activation of Rac leading to lamellipodia. Expand
LKB1, the multitasking tumour suppressor kinase
  • P. Marignani
  • Biology, Medicine
  • Journal of Clinical Pathology
  • 27 December 2004
It is evident from the recent literature that LKB1 is a multitasking kinase, with unlimited potential in orchestrating cell activity, all of which may require the tumour suppressor function of this kinase and/or its catalytic activity. Expand
Activation of tumor suppressor LKB1 by honokiol abrogates cancer stem-like phenotype in breast cancer via inhibition of oncogenic Stat3
The first in vitro and in vivo evidence to support crosstalk between LKB1, Stat3 and pluripotency factors in breast cancer and effective anticancer modulation of this axis with HNK treatment is presented. Expand
Association of Protein Kinase Cμ with Type II Phosphatidylinositol 4-Kinase and Type I Phosphatidylinositol-4-phosphate 5-Kinase*
A novel model in which the non-catalytic region of PKCμ acts as a scaffold for assembly of enzymes involved in phosphoinositide synthesis at specific membrane locations is suggested. Expand
Assessing the carcinogenic potential of low-dose exposures to chemical mixtures in the environment: the challenge ahead
Summary Low-dose exposures to common environmental chemicals that are deemed safe individually may be combining to instigate carcinogenesis, thereby contributing to the incidence of cancer. This riskExpand
Acyl chain dependence of diacylglycerol activation of protein kinase C activity in vitro.
It is demonstrated that sn-2 substitutions in DAG by specific n-3 and n-6 polyunsaturated fatty acids increase the potency of DAG to stimulate PKC activity in vitro. Expand
Loss of lkb1 Expression Reduces the Latency of ErbB2-Mediated Mammary Gland Tumorigenesis, Promoting Changes in Metabolic Pathways
Analysis of STK11−/−/NIC mammary tumors revealed hyperactivation of mammalian target of rapamycin (mTOR) through both mTORC1 and m TORC2 pathways as determined by the phosphorylation status of ribosomal protein S6 and AKT, suggestive that loss of LKB1 expression may serve as a marker for hyperactivated mTOR in HER2 positive breast cancer. Expand