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Endocrine side effects induced by immune checkpoint inhibitors.
TLDR
Hypophysitis has emerged as a distinctive side effect of CTLA4-blocking antibodies, establishing a new form of autoimmune pituitary disease in patients affected by advanced cutaneous melanoma. Expand
Listeriosis in 225 non-pregnant patients in 1992: clinical aspects and outcome in relation to predisposing conditions.
TLDR
Clinical aspects and outcome of listeriosis vary within these groups and depend on the severity of each underlying disease, although classification based on the degree of alteration of T-cell-mediated immunity enables determination of the role of predisposing conditions in cases of listersiosis outside of pregnancy. Expand
Physical Exercise and Quality of Life in Breast Cancer Survivors
TLDR
Assessment of physical exercise and quality of life in a population of female breast cancer survivors, followed up from diagnosis to the off-treatment time period, and investigated about their exercise habits in pre-diagnosis indicated significant differences across the cancer-relevant time-periods. Expand
Immunological and biological changes during ipilimumab treatment and their potential correlation with clinical response and survival in patients with advanced melanoma
TLDR
Changes in some immunological markers between baseline and the fourth ipilimumab infusion appear to be associated with disease control and survival, but verification in prospective clinical trials is required. Expand
Weekly administration of paclitaxel: theoretical and clinical basis.
TLDR
Clinical studies show that weekly paclitaxel is effective and that toxicity is acceptable, and this dose-dense approach to treatment may inhibit tumor regrowth between cycles and limit the emergence of malignant cell populations resistant to chemotherapy. Expand
Chemotherapy for glioblastoma: current treatment and future perspectives for cytotoxic and targeted agents.
TLDR
The current results with cytotoxic and targeted molecular agents in glioblastoma and the development of new chemoradiation strategies under evaluation to increase their effectiveness are summarized. Expand
Endocrine side-effects of anti-cancer drugs: mAbs and pituitary dysfunction: clinical evidence and pathogenic hypotheses.
TLDR
Hypophysitis, a previously very rare disease, has emerged as a distinctive side-effect of ipilimumab and tremelimumab, two mAbs inhibiting the cytotoxic T-lymphocyte antigen-4 receptor, being occasionally seen with nivolumab, another immune checkpoint inhibitor. Expand
Clinical experience with ipilimumab 3 mg/kg: real-world efficacy and safety data from an expanded access programme cohort
TLDR
Data from this large cohort of patients support clinical trial evidence that ipilimumab can induce durable disease control and long-term survival in patients who have failed to respond to prior treatment. Expand
Evidence of a founder mutation of BRCA1 in a highly homogeneous population from southern Italy with breast/ovarian cancer
TLDR
The identification of a founder mutation in a geographically and historically homogeneous population from Calabria, a south Italian region suggests the usefulness of founder mutations as a potential tool for optimisation of preclinical diagnosis in gene carriers and therapeutic approaches in affected individuals. Expand
Early onset pancreatic cancer: risk factors, presentation and outcome.
TLDR
EOPC seems related to active and early smoking but not to familial syndromes, resulting in similar stage-specific survival probability and young patients display aggressive disease but not worse outcome. Expand
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