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miR-196b/miR-1290 participate in the antitumor effect of resveratrol via regulation of IGFBP3 expression in acute lymphoblastic leukemia.
Evidence is provided that resveratrol targets miR-196b andmiR-1290 for its antitumor activity in T-ALL and B-ALL, respectively and also confirms that both miR‑ 196b and miR -1290 target the IGFBP3 3'-UTR and are potential therapeutic targets for ALL.
MicroRNA-148b enhances the radiosensitivity of non-Hodgkin's Lymphoma cells by promoting radiation-induced apoptosis
Results demonstrate that miR-148b increased the radiosensitivity of NHL cells probably by promoting radiation-induced apoptosis, which suggests thatMiR- 148b plays an important role in the response of NHL to ionizing radiation.
Vascular and perivascular niches, but not the osteoblastic niche, are numerically restored following allogeneic hematopoietic stem cell transplantation in patients with aplastic anemia
- Liangliang Wu, W. Mo, Shunqing Wang
- Medicine, BiologyInternational Journal of Hematology
- 16 March 2017
Vascular and perivascular niches are numerically restored, but the endosteal niche remains numerically impaired in patients with AA after allo-HSCT, and that levels of VEGF, but not donor-derived BM-MSCs, may correlate with the restoration of BM niches.
Detection of erythrocytes in patients with multiple myeloma using atomic force microscopy.
There were dramatic deformations in the overall shape and surface membrane of the erythrocytes from pre- and post therapeutic MM patients compared with the healthy controls, and AFM was able to detect noticeable morphological differences in the red blood cells from MM patientsCompared with healthy controls.
Interleukin-3 plays dual roles in osteoclastogenesis by promoting the development of osteoclast progenitors but inhibiting the osteoclastogenic process.
Detection of erythrocytes in patient with iron deficiency anemia using atomic force microscopy.
The purpose of this study was to show that pathophysiological changes to erythrocytes could be detected at the nanometer scale, which is important for the early diagnosis and effective therapies of the anemia.
miR-196 b / miR-1290 participate in the antitumor effect of resveratrol via regulation of IGFBP 3 expression in acute lymphoblastic leukemia
Evidence is provided that resveratrol targets miR196b and miR-1290 for its antitumor activity in T-ALL and B-ALL, respectively and targets the IGFBP3 3'-UTR and are potential therapeutic targets for ALL.
Sustained and stable hematopoietic donor‐recipient mixed chimerism after unrelated cord blood transplantation for adult patients with severe aplastic anemia
This study shows that durable donor‐recipient stable mixed chimerism can be achieved by unrelated CBSCT in patients with SAA, and Umbilical cord blood could be employed as a source of hematopoietic stem cell for adult transplantation.
Umbilical cord blood transplant for adult patients with severe aplastic anemia using anti-lymphocyte globulin and cyclophosphamide as conditioning therapy
Allo-CBSCT (cord blood stem cell transplant) has been applied in six adult patients with severe aplastic anemia (SAA) and four patients are alive and disease free after a median follow up of 20 months.