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Oligodendroglia metabolically support axons and contribute to neurodegeneration
It is shown that the most abundant lactate transporter in the central nervous system, monocarboxylate transporter 1 (MCT1, also known as SLC16A1), is highly enriched within oligodendroglia and that disruption of this transporter produces axon damage and neuron loss in animal and cell culture models.
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.
Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation
Activity‐dependent regulation of energy metabolism by astrocytes: An update
Very recent experimental evidence as well as theoretical arguments strongly supporting the original astrocyte‐neuron lactate shuttle concept are reviewed, with new perspectives offered by the application of this concept.
In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration
The HITI method presented here establishes new avenues for basic research and targeted gene therapies and demonstrates the efficacy of HITI in improving visual function using a rat model of the retinal degeneration condition retinitis pigmentosa.
Evidence Supporting the Existence of an Activity-Dependent Astrocyte-Neuron Lactate Shuttle
Mounting evidence from in vitro experiments indicates that lactate is an efficient energy substrate for neurons and that it may significantly contribute to maintain synaptic transmission,…
Comparison of Lactate Transport in Astroglial Cells and Monocarboxylate Transporter 1 (MCT 1) Expressing Xenopus laevis Oocytes
Comparison of lactate transport in MCT1 expressing oocytes with lactate Transport in glial cells revealed that MCT 1 can account for all characteristics of lactates transport inglial cells, providing further molecular support for the existence of a lactate shuttle between astrocytes and neurons.
Astrocyte–neuron metabolic relationships: for better and for worse
Energy on Demand
The Perspective of Magistretti et al. deduce some of the cellular and molecular events that accompany neuronal activity in the working brain, ultimately laying the groundwork for determining the biochemistry that underlies human cognition.
Aquaporins in Brain: Distribution, Physiology, and Pathophysiology
- J. Badaut, F. Lasbennes, P. Magistretti, L. Regli
- BiologyJournal of cerebral blood flow and metabolism…
- 1 April 2002
Reports suggest that water homeostasis in the brain is maintained by regulatory processes that, by control of aquaporin expression and distribution, induce and organize water movements.