Share This Author
Glutamate uptake into astrocytes stimulates aerobic glycolysis: a mechanism coupling neuronal activity to glucose utilization.
It is reported that glutamate, in addition to its receptor-mediated actions on neuronal excitability, stimulates glycolysis--i.e., glucose utilization and lactate production--in astrocytes and is consistent with data obtained from functional brain imaging studies indicating local nonoxidative glucose utilization during physiological activation.
Cellular mechanisms of brain energy metabolism and their relevance to functional brain imaging.
- P. Magistretti, L. Pellerin
- Biology, ChemistryPhilosophical transactions of the Royal Society…
- 29 July 1999
The proposed model provides a direct mechanism to couple synaptic activity with glucose use and is consistent with the notion that the signals detected during physiological activation with 18F-deoxyglucose (DG)-PET may reflect predominantly uptake of the tracer into astrocytes.
Metabolic coupling between glia and neurons
The aim of this review was to establish a chronology of events leading to and following the publication of the LNDC-REVIEW in 1996.
Similar perisynaptic glial localization for the Na+,K+-ATPase alpha 2 subunit and the glutamate transporters GLAST and GLT-1 in the rat somatosensory cortex.
It is demonstrated that alpha(2), GLAST and GLT-1 have comparable perisynaptic distribution within cortical astrocytes most likely associated with glutamatergic synapses.
Cell-specific localization of monocarboxylate transporters, MCT1 and MCT2, in the adult mouse brain revealed by double immunohistochemical labeling and confocal microscopy
Cellular bases of brain energy metabolism and their relevance to functional brain imaging: evidence for a prominent role of astrocytes.
Energy Metabolism Reference LNDC-REVIEW-1996-003 is used as a reference for energy metabolism research in women and energy-related diseases.
Vasoactive intestinal peptide and noradrenaline exert long-term control on glycogen levels in astrocytes: blockade by protein synthesis inhibition
This observation, taken together with the fact that dibutyryl-cAMP application also results in enhanced glycogen resynthesis, strongly suggests that the long-term effect of VIP or NA is mediated by the cAMP second-messenger pathway.
Modulation of the glutamate-evoked release of arachidonic acid from mouse cortical neurons: involvement of a pH-sensitive membrane phospholipase A2
- N. Stella, L. Pellerin, P. Magistretti
- Biology, ChemistryThe Journal of neuroscience : the official…
- 1 May 1995
Results indicate that the glutamate-evoked release of 3H-AA may be mediated by the pH- sensitive mPLA2, and reveals a possible molecular mechanism whereby glutamate can modulate its own signalling efficacy in a pH-dependent manner by regulating the release of AA.
Vasoactive intestinal peptide, pituitary adenylate cyclase-activating peptide, and noradrenaline induce the transcription factors CCAAT/enhancer binding protein (C/EBP)-beta and C/EBP delta in mouse…
The results support the idea that C/EBP beta and -delta regulate gene expression of energy metabolism-related enzymes in astrocytes, and induce the cAMP second-messenger pathway.
Excitatory amino acids stimulate aerobic glycolysis in astrocytes via an activation of the Na+/K+ ATPase.
The pharmacological characteristics and molecular mechanisms of this action, which involve a massive influx of Na+ as a result of the cotransport of the amino acid with Na+, by Na(+)-dependent transporters and a subsequent activation of the Na+/K+ ATPase, reveal a simple mechanism for coupling neuronal activity to glucose utilization.