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Biomechanical forces promote embryonic haematopoiesis
Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in the developing cardiovascular system. After initiation of the heartbeat in vertebrates, cells lining theExpand
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Cell migration into scaffolds under co-culture conditions in a microfluidic platform.
Capillary morphogenesis is a complex cellular process that occurs in response to external stimuli. A number of assays have been used to study critical regulators of the process, but those assays areExpand
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Hemodynamic Environments from Opposing Sides of Human Aortic Valve Leaflets Evoke Distinct Endothelial Phenotypes In Vitro
The regulation of valvular endothelial phenotypes by the hemodynamic environments of the human aortic valve is poorly understood. The nodular lesions of calcific aortic stenosis (CAS) developExpand
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Autoimmune hemolytic anemia: a history.
UTOIMMUNE HEMOLYTIC anemia (AIHA) is an acquired immunoIogic disease in which the patient's red blood cells (RBCs) are selectively attacked and destroyed (hemolyzed) by autoantibodies produced by theExpand
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Biomechanical Regulation of Endothelium-dependent Events Critical for Adaptive Remodeling*
Alterations in hemodynamic shear stress acting on the vascular endothelium are critical for adaptive arterial remodeling. The molecular mechanisms regulating this process, however, remain largelyExpand
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Functional endothelialized microvascular networks with circular cross-sections in a tissue culture substrate
Functional endothelialized networks constitute a critical building block for vascularized replacement tissues, organ assist devices, and laboratory tools for in vitro discovery and evaluation of newExpand
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Force-induced focal adhesion translocation: effects of force amplitude and frequency.
Vascular endothelial cells rapidly transduce local mechanical forces into biological signals through numerous processes including the activation of focal adhesion sites. To examine the mechanosensingExpand
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Exploring the molecular basis for mechanosensation, signal transduction, and cytoskeletal remodeling.
Living cells respond to mechanical stimulation in a variety of ways that affect nearly every aspect of their function. Such responses can range from changes in cell morphology to activation ofExpand
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force amplitude and frequency Force-induced focal adhesion translocation : effects of
[PDF] [Full Text] [Abstract] , April 1, 2005; 98 (4): 1554-1561. J Appl Physiol A. C. Bellott, K. C. Patel and T. J. Burkholder ERK2 in skeletal muscle myotubes Reduction of caveolin-3 expressionExpand
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