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Modulation of cisplatin cytotoxicity and cisplatin-induced DNA cross-links in HepG2 cells by regulation of glutathione-related mechanisms.
Glutathione (GSH), glutathione S-transferase (GST), and glutathione conjugate export pump (GS-X pump) have been shown to participate collectively in the detoxification of many anticancer drugs,Expand
Daphnetin, one of coumarin derivatives, is a protein kinase inhibitor.
Protein kinases play key roles in the control of cell proliferation, differentiation and metabolism. In this work, we studied the effect of coumarin and its derivatives, including daphnetin, esculin,Expand
Glutathione-related mechanisms in cellular resistance to anticancer drugs.
Glutathione conjugation and transport of glutathione conjugates of anticancer drugs out of cells have been shown to work as a system in the detoxification of many anticancer drugs. The majorExpand
Angiopoietin 1 promotes tumor angiogenesis and tumor vessel plasticity of human cervical cancer in mice.
Angiopoietins have been increasingly implicated to play important roles in blood vessel formation, remodeling, maturation, and maintenance. However, their roles in tumor angiogenesis and hence tumorExpand
Inhibition of glutathione reductase by plant polyphenols.
The effects of forty-one plant polyphenols on the activity of glutathione reductase (GSH-RD) were studied. These polyphenols showed varying degrees of concentration-dependent inhibition on theExpand
Apoptosis induced by hyperthermia in Dunn osteosarcoma cell line in vitro
  • Y. Rong, P. Mack
  • Chemistry, Medicine
  • International journal of hyperthermia : the…
  • 1 January 2000
The effect of hyperthermia at 43.5oC for 1h on Dunn osteosarcoma cells was studied. With sham-heated cells (37oC, 1h) as the control, the hyperthermia treated cells were divided into five groups.Expand
Butein, a specific protein tyrosine kinase inhibitor.
Butein, a plant polyphenol, was shown to be a specific protein tyrosine kinase inhibitor. This compound inhibited not only the epidermal growth factor (EGF)-stimulated auto-phosphotyrosine level ofExpand
Inhibition of epidermal growth factor receptor tyrosine kinase by chalcone derivatives.
In our previous study, butein, a chalcone derivative, was found to be an inhibitor of tyrosine kinases and the inhibition was ATP-competitive. In this work, chalcone and seven chalcone derivativesExpand
Norcantharidin inhibits growth of human HepG2 cell-transplanted tumor in nude mice and prolongs host survival.
In this study, norcantharidin was compared with adriamycin and mitomycin C for its inhibitory action in the growth of cultured human hepatocellular carcinoma HepG2 cells. The IC50 of adriamycin andExpand
Inhibition of angiopoietin‐1 expression in tumor cells by an antisense RNA approach inhibited xenograft tumor growth in immunodeficient mice
Angiopoietin‐1 (Ang1) is an angiogenic growth factor that functions through activation of its endothelium‐specific tyrosine kinase receptor Tie2; it mediates the interaction between endothelial andExpand