• Publications
  • Influence
A study of angiotensin II pressor response throughout primigravid pregnancy.
In both groups, vascular resistance to infused angiotensin II (more than 8 ng/kg/min required to elicit a pressor response of 20 mm Hg in diastolic pressure) was demonstrated as early as the 10th wk of pregnancy, with a clear separation of the two groups by the 22nd wk. Expand
Maternal plasma adrenocorticotropin and cortisol relationships throughout human pregnancy.
The rise in plasma ACTH concentrations, asregnancy advances, is suggestive of the possibility that a source of ACTH exists that is not subject to negative feedback control, that the clearance of free cortisol increases as pregnancy advances, or that there is an alteration in the metabolism of the ACTH precursor protein produced by the pituitary and/or placenta. Expand
Source of estrogen production in postmenopausal women.
Aromatization of androstenedione by human adipose tissue stromal cells in monolayer culture.
The ability of human adipose tissue to form estrogen is not a function primarily of the adipocytes but rather resides principally in the cells of the stroma. Expand
Familial incomplete male pseudohermaphroditism, type 2. Decreased dihydrotestosterone formation in pseudovaginal perineoscrotal hypospadias.
The demonstration of markedly deficient dihydrotestosterone formation in slices of perineal skin, epididymis and phallus, is compatible with the fact that dihydotestosterone is the fetal hormone responsible for male differentiation of the external genitalia, iscompatible with the idea that androgen resistance in this syndrome is different from that in other androgen-resistant states. Expand
Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.
It is found that cachectin/tumor necrosis factor-alpha (TNF-alpha) was synthesized and secreted into the culture medium by human decidual cells and explants in response to treatment with LPS, and may serve a fundamental role in the pathogenesis of preterm labor, including increased prostaglandin formation and premature rupture of the membranes. Expand
17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium.
The chromosomal localization of human 17 beta-HSD type 2, the expression of this gene in human endometrium, and the tissue distribution of the mRNA are determined, consistent with the view that the progestin-regulated 17 alpha-hydroxyl group of the glandular epithelium of the human Endometrium is primarily, if not exclusively, the product of the 17beta-HSd type 2 gene. Expand
Cellular localization of membrane metalloendopeptidase (enkephalinase) in human endometrium during the ovarian cycle.
It is demonstrated that in the late secretory phase in decidualizing stroma, MMEP-IR is decreased considerably compared with midsecretory stromal cells, which is supportive of a role for MMEP in paracrine interactions affecting vascular homeostasis in the endometrium. Expand
Origin of estrogen in normal men and in women with testicular feminization.
The purpose of this study was to quantify the various sources of estrone (E1) and 17 beta-estradiol (E2) production in normal men and in women with testicular feminization. The mean production rateExpand
Regulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures
The potential for synthesis of monocyte chemotactic protein-1 (MCP-1), a polypeptide with monocyte/macrophageChemotactic and activating properties, in human endometrium and in separated endometrial stromal and epithelial cells is evaluated. Expand