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The trinity of COVID-19: immunity, inflammation and intervention
The interaction of SARS-CoV-2 with the immune system and the subsequent contribution of dysfunctional immune responses to disease progression is described and the implications of these approaches for potential therapeutic interventions that target viral infection and/or immunoregulation are highlighted.
Latency, chromatin remodeling, and reactivation of human cytomegalovirus in the dendritic cells of healthy carriers.
- M. Reeves, P. MacAry, P. Lehner, J. Sissons, J. Sinclair
- BiologyProceedings of the National Academy of Sciences…
- 15 March 2005
Evidence is presented to show that myeloid dendritic cell (DC) progenitors are sites of HCMV latency and that their ex vivo differentiation to a mature DC phenotype is linked with reactivation of infectious virus resulting from differentiation-dependent chromatin remodeling of the viral major immediate-early promoter.
CD40 is a cellular receptor mediating mycobacterial heat shock protein 70 stimulation of CC-chemokines.
The genomic landscape of nasopharyngeal carcinoma
The mutational landscape of 128 cases with NPC is determined using whole-exome and targeted deep sequencing, as well as SNP array analysis, which revealed a distinct mutational signature and nine significantly mutated genes, many of which have not been implicated previously in NPC.
Loss of function of a lupus-associated FcγRIIb polymorphism through exclusion from lipid rafts
It is shown that a recently described SLE-associated polymorphism of FcγRIIb (Fcγ RIIbT232), encoding a single transmembrane amino acid substitution, is functionally impaired and unable to inhibit activatory receptors.
Current Views on the Clinical Relevance of Blastocystis spp.
- K. Tan, H. Mirza, J. Teo, Binhui Wu, P. MacAry
- Biology, MedicineCurrent infectious disease reports
- 27 January 2010
The controversial pathogenesis of Blastocystis is attributed to subtype variations in virulence; although current studies seem to support this idea, evidence suggests other factors also contribute to the clinical outcome of the infection.
The Structural Basis for Serotype-Specific Neutralization of Dengue Virus by a Human Antibody
Describing the isolation of a neutralizing antibody from a DENV1-infected patient and demonstrating that the antibody binds across two adjacent viral envelope proteins and identifying the amino acids that comprise the binding site provide a structural and molecular context for durable, serotype-specific immunity to DENV infection.
Differential Targeting of Viral Components by CD4+ versus CD8+ T Lymphocytes in Dengue Virus Infection
During a dengue virus infection, the protein targets of human CD4+ and CD8+ T cells are largely distinct, thus highlighting key differences in the immunodominance of DENV proteins for these two cell types has important implications for understanding how the two arms of the human adaptive immune system are differentially targeted and employed as part of the response to DENV infection.
Lung CD103+ Dendritic Cells Efficiently Transport Influenza Virus to the Lymph Node and Load Viral Antigen onto MHC Class I for Presentation to CD8 T Cells
Results show that CD11blow/negCD103+ DCs are functionally specialized for the transport of Ag from the lung to the lymph node and also for efficient processing and presentation of viral Ags to CD8 T cells.
A CD8 T cell transcription signature predicts prognosis in autoimmune disease
It is shown that transcriptional profiling of purified CD8+ T cells, which avoids the confounding influences of unseparated cells, identifies two distinct subject subgroups predicting long-term prognosis in two autoimmune diseases, antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) and systemic lupus erythematosus (SLE).