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Statin and rottlerin small-molecule inhibitors restrict colon cancer progression and metastasis via MACC1
MACC1 (Metastasis Associated in Colon Cancer 1) is a key driver and prognostic biomarker for cancer progression and metastasis in a large variety of solid tumor types, particularly colorectal cancerExpand
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Uptake, biodistribution, and time course of naked plasmid DNA trafficking after intratumoral in vivo jet injection.
Nonviral jet injection is an applicable technology for in vivo gene transfer of naked DNA. However, little is known about the biodistribution and clearance of jet-injected DNA, or about itsExpand
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Cell surface α2,6-sialylation affects adhesion of breast carcinoma cells
Abstract Tumor-associated alterations of cell surface glycosylation play a crucial role in the adhesion and metastasis of carcinoma cells. The aim of this study was to examine the effect ofExpand
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Multiphoton excitation and photodynamic activity of macromolecular derivatized mTHPC
Multiphoton excitation of photosensitizers in photodynamic therapy constitutes a promising approach, because of the increasing tissue penetration for longer wavelength of illumination. In thisExpand
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Optical Characterization of Breast Tumors by Frequency-Domain Optical Mammography
We present a method aimed at the non-invasive optical characterization of breast tumors. This method is based on using diffusion theory to model the propagation of intensity-modulated light in breastExpand
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Integrins and E-Cadherin Expression – A Way for the Better Understanding of the Biological Behaviour of Colorectal Cancer
Colorectal carcinoma ranks second in frequency among all malignant tumors in the developed industrial countries. Determination of tumor cell differentiation together with pathological and clinicalExpand
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Active Specific Immunotherapy with Autologous Tumor Cell Vaccines Modified by Newcastle Disease Virus: Experimental and Clinical Studies
Active specific immunotherapy (ASI) procedures usually involve active vaccination with intact, but inactivated tumor cells or with tumor-derived subcellular membrane fractions. Such material isExpand
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Inhibition of Galβ1,4GlcNAc α2,6 sialyltransferase expression by antisense‐oligodeoxynucleotides
Treatment of human colorectal carcinoma cells HT29 with specific antisense oligodeoxynucleotides led to a decreased Galβ1,4GlcNAc α2,6 sialyltransferase activity on the level of protein expression asExpand
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HER2/neu DNA vaccination by intradermal gene delivery in a mouse tumor model
DNA vaccines are potential tools for the induction of immune responses against both infectious disease and cancer. The dermal application of DNA vaccines is of particular interest since the epidermalExpand
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