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Phenobarbital mechanistic data and risk assessment: enzyme induction, enhanced cell proliferation, and tumor promotion.
Chronic exposure to high doses of phenobarbital (PB) causes hepatocellular adenomas in both mice and rats and hepatocellular carcinomas in some strains of mice. Long-term PB therapy has not beenExpand
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Genotoxicity of benzene and its metabolites.
The potential role of genotoxicity in human leukemias associated with benzene (BZ) exposures was investigated by a systematic review of over 1400 genotoxicity test results for BZ and its metabolites.Expand
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Evaluation of possible genotoxic mechanisms for acrylonitrile tumorigenicity.
Acrylonitrile (ACN) exposure is associated with tumors in rat brain, Zymbal gland, and mammary gland. Adducts affecting base pairing were formed in isolated DNA exposed in vitro to the ACN metaboliteExpand
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Pathogenesis of methionine-induced toxicity.
Abstract L-methionine 10 mMole/Kg. per day administered orally to guinea pigs leads to a state characterized early by fatty liver, hypoglycemia and aminoacidemia and later by hypothermia, profoundExpand
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Olfaction and symptoms in the multiple chemical sensitivities syndrome.
Whereas most idiosyncratic environmental sensitivity complaints do not fit known diagnoses, the multiple chemical sensitivities syndrome (MCS) is an extreme presentation that has defined diagnosticExpand
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Genotoxicity studies with the antiestrogen toremifene.
Toremifene, a second-generation triphenylethylene antiestrogen used clinically in the chemotherapy of breast cancer and some other cancers, differs in its nonclinical toxicology from itsExpand
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Fractures and dislocations involving the navicular-lunate axis.
This is a report of experience with 48 carpal disruptions including anterior dislocations of the lunate, transnavicular perilunate and perilunate dislocations and subluxation of the navicular. TheExpand
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Slipped capital femoral epiphysis long-term results after 10--38 years.
Thirty-four patients with chronic slipped capital femoral epiphysis (SCFE) involving 45 hips were followed over a period of no less than 10 years and as great as 38 years. Excluding those who had hadExpand
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Vertebral body osteomyelitis: spectrum and natural history. A retrospective analysis of 37 cases.
There has been a definite change in the natural history of vertebral osteomyelitis. At the turn of the century the disease was most often seen in younger people, accompanied by a high incidence ofExpand
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