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1,25-Dihydroxyvitamin D3 Suppresses Telomerase Expression and Human Cancer Growth through MicroRNA-498*
- Ravi Kasiappan, Zheng Shen, W. Bai
- Biology, MedicineThe Journal of Biological Chemistry
- 10 October 2012
A new mechanism of telomerase regulation through non-coding small RNA is revealed by showing that microRNA-498 (miR-498) induced by 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) decreases the mRNA expression of the human telomersase reverse transcriptase.
Molecular cloning and characterization of an allatostatin-like receptor in the cockroach Diploptera punctata
Vitamin D suppresses leptin stimulation of cancer growth through microRNA.
- Ravi Kasiappan, Yuefeng Sun, P. Lungchukiet, Waise Quarni, X. Zhang, W. Bai
- Biology, MedicineCancer research
- 1 November 2014
The studies suggest that vitamin D may be an effective agent to reduce obesity-associated cancer risks in women and suggest that miR-498-mediated hTERT downregulation is a key event mediating the anti-leptin activity of 1,25(OH)2D3 in estrogen-sensitive tumors in women.
Extracellular Calcium-Sensing Receptor Inhibition of Intestinal EpithelialTNF Signaling Requires CaSR-Mediated Wnt5a/Ror2 Interaction
Following LPS challenge, CaSR activation will inhibit NFκB activity and reduce TNFα secretion from macrophages and stroma while Wnt5a/Ror2 engagement on intestinal epithelia reduces TNFR1 expression, allowing TNF α signaling to be titrated.
Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation
Mechanistic studies suggest that the suppression of breast cancer cell migration and invasion is mediated through its phosphotyrosine binding domain 1 that mediates the recruitment of Tip60 to cortactin to stimulate its acetylation.
Quantification of allatostatin receptor mRNA levels in the cockroach, Diploptera punctata, using real-time PCR.
Suppression of epithelial ovarian cancer invasion into the omentum by 1α,25-dihydroxyvitamin D3 and its receptor
Immunolocalization of allatostatin-like neuropeptides and their putative receptor in eyestalks of the tiger prawn, Penaeus monodon
CaSR covalently modifies Wntless (Wls) to differentially regulate Wnt5a and Wnt3a secretion
Redesign of an Interhelical Loop of the Bacillus thuringiensis Cry4B delta-endotoxin for Proteolytic Cleavage
The mosquito larvicidal assay against Aedes aegypti demonstrated a relatively unchanged toxicity for the mutants without cleavage and reduced toxicity for those with an additional cleavage.