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trans-5-aminopipecolyl-aegPNA chimera: design, synthesis, and study of binding preferences with DNA/RNA in duplex/triplex mode.
The design and synthesis of novel chiral PNA monomer based on trans-5-aminopipecolic acid is reported. The trans diequatorial disposition of the 1,4 ring substituents in six-membered 5-aminopipecolicExpand
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CONSTRAINED FLEXIBILITY IN PNA: DNA BINDING STUDIES WITH BRIDGED AMINOPROPYLGLYCYL PNA
Introduction of methylene bridges in aegPNA and apgPNA molecules give rise to cyclic five and six membered ring structures. Synthesis of a new six membered cyclic PNA monomer, aminopipecolyl PNAExpand
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Chimeric (aeg-pyrrolidine)PNAs: synthesis and stereo-discriminative duplex binding with DNA/RNA.
The design and facile conversion of naturally occurring 4-hydroxyproline to all four diastereomers of thymine pyrrolidine PNA monomer, (2R,4S)-adenine, -guanine and -cytosine monomers and theirExpand
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Design and synthesis of conformationally frozen peptide nucleic acid backbone: chiral piperidine PNA as a hexitol nucleic acid surrogate.
  • P. Lonkar, V. Kumar
  • Chemistry, Medicine
  • Bioorganic & medicinal chemistry letters
  • 3 May 2004
The design and facile synthesis of novel chiral piperidine PNA from naturally occurring 4-hydroxy-L-proline is reported. The stereospecific ring-expansion reaction to get six-membered piperidineExpand
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Disease profile of a sheep flock in semi-arid India
Abstract The development of sheep flock health programs requires information on diseases occurring in the flock. This information has to be in the form of profiles so as to indicate the importance ofExpand
  • 12
Piperidinyl Peptide Nucleic Acids: Synthesis and DNA-Complementation Studies
  • P. Lonkar, V. Kumar
  • Chemistry, Medicine
  • Nucleosides, nucleotides & nucleic acids
  • 1 May 2003
Abstract Synthesis of a new six membered PNA analogue by introducing a methylene bridge between β carbon atom of ethylene diamine and β′ carbon atom of linker to nucleobase.
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