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Toll-Like Receptor Triggering of a Vitamin D-Mediated Human Antimicrobial Response
In innate immune responses, activation of Toll-like receptors (TLRs) triggers direct antimicrobial activity against intracellular bacteria, which in murine, but not human, monocytes and macrophagesExpand
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Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
An essential element of the innate immune response to injury is the capacity to recognize microbial invasion and stimulate production of antimicrobial peptides. We investigated how this process isExpand
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Toll-like Receptors Induce a Phagocytic Gene Program through p38
Toll-like receptor (TLR) signaling and phagocytosis are hallmarks of macrophage-mediated innate immune responses to bacterial infection. However, the relationship between these two processes is notExpand
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Vitamin D Is Required for IFN-γ–Mediated Antimicrobial Activity of Human Macrophages
Vitamin D is required for both innate and adaptive immunity to tuberculosis. The Sunny Side of Antimicrobial Response Nearly one-third of the world’s population is thought to be infected withExpand
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Convergence of IL-1β and VDR Activation Pathways in Human TLR2/1-Induced Antimicrobial Responses
Antimicrobial effector mechanisms are central to the function of the innate immune response in host defense against microbial pathogens. In humans, activation of Toll-like receptor 2/1 (TLR2/1) onExpand
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TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells
Leprosy enables investigation of mechanisms by which the innate immune system contributes to host defense against infection, because in one form, the disease progresses, and in the other, theExpand
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Cutting Edge: Vitamin D-Mediated Human Antimicrobial Activity against Mycobacterium tuberculosis Is Dependent on the Induction of Cathelicidin1
Host defense against intracellular pathogens depends upon innate and adaptive antimicrobial effector pathways. TLR2/1-activation of monocytes leads to the vitamin D-dependent production ofExpand
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Activation and regulation of Toll-like receptors 2 and 1 in human leprosy
The expression and activation of Toll-like receptors (TLRs) was investigated in leprosy, a spectral disease in which clinical manifestations correlate with the type of immune response mounted towardExpand
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Vitamin D-Directed Rheostatic Regulation of Monocyte Antibacterial Responses1
The active form of vitamin D, 1,25-dihydroxyvitamin D (1,25(OH)2D) enhances innate immunity by inducing the cathelicidin antimicrobial peptide (hCAP). In monocytes/macrophages, this occurs primarilyExpand
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T-cell cytokines differentially control human monocyte antimicrobial responses by regulating vitamin D metabolism
We investigated the mechanisms by which T-cell cytokines are able to influence the Toll-like receptor (TLR)-induced, vitamin D-dependent antimicrobial pathway in human monocytes. T-cell cytokinesExpand
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