The versatility and universality of calcium signalling
The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
Calcium - a life and death signal
This research investigates how the calcium ion regulates cell birth, life and death, and how it regulates so many different cellular processes in the human body.
Calcium signalling--an overview.
To generate the variety of observed Ca2+ signals, different cell types employ components selected from aCa2+ signalling 'toolkit', which comprizes an array of signalling, homeostatic and sensory mechanisms.
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
Imaging the hierarchical Ca2+ signalling system in HeLa cells.
The hierarchy of Ca2+ signalling events, from fundamental levels (blips) to intermediate levels (puffs) to Ca2- waves, is a prototype forCa2+ signal transduction for non‐excitable cells, and is also analogous to the Ca2+.
Mitochondria are morphologically and functionally heterogeneous within cells
The data indicate that mitochondria within individual cells are morphologically heterogeneous and unconnected, allowing them to have distinct functional properties.
Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart
Cooking with Calcium: The Recipes for Composing Global Signals from Elementary Events
The role of inositol 1,4,5‐trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes
It is concluded that the particular spatial profile of cellular Ca2+ signals is a major, previously unrecognised, determinant for arrhythmogenic potency and that the InsP3 signalling cassette might therefore be a promising new target for understanding and managing atrial arrhythmia.