The versatility and universality of calcium signalling
- M. Berridge, P. Lipp, M. Bootman
- BiologyNature reviews. Molecular cell biology
- 1 October 2000
The universality of calcium as an intracellular messenger depends on its enormous versatility, which is exploited to control processes as diverse as fertilization, proliferation, development, learning and memory, contraction and secretion.
Calcium - a life and death signal
- M. Berridge, M. Bootman, P. Lipp
- BiologyNature
- 15 October 1998
This research investigates how the calcium ion regulates cell birth, life and death, and how it regulates so many different cellular processes in the human body.
Calcium signalling--an overview.
- M. Bootman, T. Collins, P. Lipp
- BiologySeminars in Cell and Developmental Biology
- 1 February 2001
To generate the variety of observed Ca2+ signals, different cell types employ components selected from aCa2+ signalling 'toolkit', which comprizes an array of signalling, homeostatic and sensory mechanisms.
Calcium signalling
- M. Berridge, P. Lipp, M. Bootman
- BiologyCurrent Biology
- 11 March 1999
Identification of ARAP3, a novel PI3K effector regulating both Arf and Rho GTPases, by selective capture on phosphoinositide affinity matrices.
- S. Krugmann, K. Anderson, P. Hawkins
- Biology, ChemistryMolecules and Cells
- 2002
Imaging the hierarchical Ca2+ signalling system in HeLa cells.
- M. Bootman, E. Niggli, M. Berridge, P. Lipp
- BiologyJournal of Physiology
- 1 March 1997
The hierarchy of Ca2+ signalling events, from fundamental levels (blips) to intermediate levels (puffs) to Ca2- waves, is a prototype forCa2+ signal transduction for non‐excitable cells, and is also analogous to the Ca2+.
Mitochondria are morphologically and functionally heterogeneous within cells
- T. Collins, M. Berridge, P. Lipp, M. Bootman
- BiologyEMBO Journal
- 1 April 2002
The data indicate that mitochondria within individual cells are morphologically heterogeneous and unconnected, allowing them to have distinct functional properties.
Functional InsP3 receptors that may modulate excitation–contraction coupling in the heart
- P. Lipp, M. Laine, M. Bootman
- BiologyCurrent Biology
- 1 August 2000
Cooking with Calcium: The Recipes for Composing Global Signals from Elementary Events
- M. Bootman, M. Berridge, P. Lipp
- BiologyCell
- 31 October 1997
The role of inositol 1,4,5‐trisphosphate receptors in Ca2+ signalling and the generation of arrhythmias in rat atrial myocytes
- L. Mackenzie, M. Bootman, P. Lipp
- Biology, MedicineJournal of Physiology
- 1 June 2002
It is concluded that the particular spatial profile of cellular Ca2+ signals is a major, previously unrecognised, determinant for arrhythmogenic potency and that the InsP3 signalling cassette might therefore be a promising new target for understanding and managing atrial arrhythmia.
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