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The DEAD-box protein family of RNA helicases.
The description of the molecular characteristics of members of the DEAD-box protein family and on the enzymatic activities they possess gives insight into the regulation of ATP and RNA binding as well as in the ATPase and helicase activities. Expand
From unwinding to clamping — the DEAD box RNA helicase family
Structural, mechanistic and molecular biological studies have started to reveal how these conserved proteins can perform such diverse functions and how accessory proteins have a central role in their regulation. Expand
DExD/H box RNA helicases: from generic motors to specific dissociation functions.
Analysis of the three-dimensional structures obtained through the crystallization of viral and cellular RNA helicases reveals a strong structural homology to DNA helicases. Expand
DEAD-box proteins: the driving forces behind RNA metabolism
  • S. Rocak, P. Linder
  • Biology, Medicine
  • Nature Reviews Molecular Cell Biology
  • 1 March 2004
RNA helicases from the DEAD-box family are found in almost all organisms and have important roles in RNA metabolism. They are associated with many processes ranging from RNA synthesis to RNAExpand
The Q motif: a newly identified motif in DEAD box helicases may regulate ATP binding and hydrolysis.
Sequence alignments, site-specific mutagenesis, and ATPase assays show that this motif and the upstream phenylalanine are highly conserved, that they are essential for viability in the yeast Saccharomyces cerevisiae, and that they control ATP binding and hydrolysis inThe yeast translation-initiation factor eIF4A. Expand
Dead-box proteins: a family affair—active and passive players in RNP-remodeling
  • P. Linder
  • Biology, Medicine
  • Nucleic acids research
  • 26 August 2006
From the genetic and biochemical data obtained mainly in yeast, it has become clear that these proteins play important roles in remodeling RNP complexes in a temporally controlled fashion. Expand
D‐E‐A‐D protein family of putative RNA helicases
A review of putative RNA helicases from different organisms ranging from Escherichia coli to humans and viruses involved in diverse cellular functions such as RNA splicing, ribosome assembly, initiation of translation, spermatogenesis, embryogenesis, and cell growth and division. Expand
Crystal structure of the human ATP-dependent splicing and export factor UAP56.
It is shown that purified human UAP56 is an active RNA-dependent ATPase, and the crystal structures reveal a unique spatial arrangement of the two conserved helicase domains, and ADP-binding induces significant conformational changes of key residues in the ATP-binding pocket. Expand
Unwinding RNA in Saccharomyces cerevisiae: DEAD-box proteins and related families.
Members of the RNA-helicase family are defined by several evolutionary conserved motifs and new insights are given into, and the significance of these proteins for, most cellular RNA metabolic processes is confirmed. Expand
Protein trans-Acting Factors Involved in Ribosome Biogenesis in Saccharomyces cerevisiae
This minireview is aimed at giving an insight into the functions of the many protein trans-acting factors involved in ribosome biogenesis in S. cerevisiae. Expand