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Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
- P. Lichtenstein, N. Holm, +6 authors K. Hemminki
- The New England journal of medicine
- 13 July 2000
Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer. Expand
Genome-wide association study identifies five new schizophrenia loci
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia. Expand
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
Evidence is shown that schizophrenia and bipolar disorder partly share a common genetic cause, which is consistent with a reappraisal of these disorders as distinct diagnostic entities. Expand
Genome-wide association study identifies 74 loci associated with educational attainment
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases. Expand
Prevalence, heritability, and prospective risk factors for anorexia nervosa.
- C. Bulik, P. Sullivan, F. Tozzi, H. Furberg, P. Lichtenstein, N. Pedersen
- Psychology, Medicine
- Archives of general psychiatry
- 1 March 2006
Individuals who survive AN and who no longer have body mass indexes in the AN range appear to be at lower risk for the development of overweight, and Prospectively assessed neuroticism was associated with the subsequent development of AN. Expand
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics. Expand
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders. Expand
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood.
- P. Lichtenstein, E. Carlström, M. Råstam, C. Gillberg, H. Anckarsäter
- Medicine, Psychology
- The American journal of psychiatry
- 1 November 2010
Different neuropsychiatric disorders seem to have a common genetic etiology, suggesting caution in the use of diagnostic entities and proband status in efforts to uncover genes predisposing to autism spectrum disorders. Expand
Rare chromosomal deletions and duplications increase risk of schizophrenia
A genome-wide survey of rare CNVs in 3,391 patients with schizophrenia and 3,181 ancestrally matched controls provides strong support for a model of schizophrenia pathogenesis that includes the effects of multiple rare structural variants, both genome- wide and at specific loci. Expand
The familial risk of autism.
- S. Sandin, P. Lichtenstein, R. Kuja‐Halkola, H. Larsson, C. Hultman, A. Reichenberg
- 7 May 2014
Among children born in Sweden, the individual risk of ASD and autistic disorder increased with increasing genetic relatedness and support for a disease etiology including only additive genetic and nonshared environmental effects was found. Expand