Environmental and heritable factors in the causation of cancer--analyses of cohorts of twins from Sweden, Denmark, and Finland.
Inherited genetic factors make a minor contribution to susceptibility to most types of neoplasms, which indicates that the environment has the principal role in causing sporadic cancer.
Genome-wide association study identifies five new schizophrenia loci
The role of common genetic variation in schizophrenia in a genome-wide association study of substantial size is examined, suggesting MIR137-mediated dysregulation as a previously unknown etiologic mechanism in schizophrenia.
Genome-wide association study identifies 74 loci associated with educational attainment
Because educational attainment is measured in large numbers of individuals, it will continue to be useful as a proxy phenotype in efforts to characterize the genetic influences of related phenotypes, including cognition and neuropsychiatric diseases.
GWAS of 126,559 Individuals Identifies Genetic Variants Associated with Educational Attainment
Three genetic loci are found to explain variation associated with educational achievement and provide promising candidate SNPs for follow-up work, and effect size estimates can anchor power analyses in social-science genetics.
Common genetic determinants of schizophrenia and bipolar disorder in Swedish families: a population-based study
Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs
Empirical evidence of shared genetic etiology for psychiatric disorders can inform nosology and encourages the investigation of common pathophysiologies for related disorders.
Prevalence, heritability, and prospective risk factors for anorexia nervosa.
- C. Bulik, P. Sullivan, F. Tozzi, H. Furberg, P. Lichtenstein, N. Pedersen
- Medicine, PsychologyArchives of General Psychiatry
- 1 March 2006
Individuals who survive AN and who no longer have body mass indexes in the AN range appear to be at lower risk for the development of overweight, and Prospectively assessed neuroticism was associated with the subsequent development of AN.
The genetics of autism spectrum disorders and related neuropsychiatric disorders in childhood.
- P. Lichtenstein, E. Carlström, M. Råstam, C. Gillberg, H. Anckarsäter
- Medicine, PsychologyAmerican Journal of Psychiatry
- 1 November 2010
Different neuropsychiatric disorders seem to have a common genetic etiology, suggesting caution in the use of diagnostic entities and proband status in efforts to uncover genes predisposing to autism spectrum disorders.
Premature mortality in autism spectrum disorder
- T. Hirvikoski, E. Mittendorfer-Rutz, M. Boman, H. Larsson, P. Lichtenstein, S. Bölte
- MedicineBritish Journal of Psychiatry
- 1 March 2016
Premature mortality was markedly increased in ASD owing to a multitude of medical conditions and Mortality and patterns for cause-specific mortality were partly moderated by gender and general intellectual ability.
The Swedish Twin Registry: a unique resource for clinical, epidemiological and genetic studies
- P. Lichtenstein, U. de Faire, B. Floderus, M. Svartengren, P. Svedberg, N. Pedersen
- MedicineJournal of Internal Medicine
- 1 September 2002
The Swedish Twin Registry is a unique resource for clinical, epidemiological and genetic studies (Review) and should be considered for further study.