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Toxicological effects of cinnabar in rats by NMR-based metabolic profiling of urine and serum.
TLDR
Findings indicated cinnabar induced disturbance in energy metabolism, amino acid metabolism and gut microflora environment as well as slight injury in liver and kidney, which might indirectly result from cinnABar induced oxidative stress. Expand
Metabolic profiling studies on the toxicological effects of realgar in rats by (1)H NMR spectroscopy.
TLDR
The toxicological effects of realgar after intragastrical administration were investigated over a 21 day period in male Wistar rats using metabonomic analysis of (1)H NMR spectra of urine, serum and liver tissue aqueous extracts to illustrated the high reliability of NMR-based metabonomic approach on the study of the biochemical effects induced by traditional Chinese medicine. Expand
NMR-based metabonomic study on the subacute toxicity of aristolochic acid in rats.
TLDR
The subacute toxicity of aristolochic acid was investigated by (1)H NMR spectroscopic and pattern recognition (PR)-based metabonomic methods and indicated that the renal proximal tubule lesion was the main damage induced by AA. Expand
NMR spectroscopic-based metabonomic investigation on the acute biochemical effects induced by Ce(NO3)3 in rats.
TLDR
The findings indicated the impairment of fatty acid beta-oxidation in liver mitochondria and renal lesions and illustrates the high reliability of NMR-based metabonomic approach on the study of the biochemical effects induced by rare earths. Expand
Chemoselective oxidative C(CO)-C(methyl) bond cleavage of methyl ketones to aldehydes catalyzed by CuI with molecular oxygen.
TLDR
This method is applicable to a wide range of aromatic and aliphatic methyl ketones and chemoselectively produces aldehydes, accompanied by the release of hydrogen (H2 ) and carbon dioxide (CO2 ) as by-products. Expand
Silver(I)-catalyzed hydroazidation of ethynyl carbinols: synthesis of 2-azidoallyl alcohols.
TLDR
A chemo- and regioselective transformation of ethynyl carbinols into vinyl azides is described, which produces a wide variety of 2-azidoallyl alcohols with high efficiency and in good to excellent yields. Expand
General silver-catalyzed hydroazidation of terminal alkynes by combining TMS-N3 and H2O: synthesis of vinyl azides.
TLDR
This reaction has a broad substrate scope, good functional group tolerance, simple operation, and high reaction efficiency, thus providing an easy access to various functionalized vinyl azides. Expand
Modular synthesis of sulfonyl benzoheteroles by silver-catalyzed heteroaromatization of propargylic alcohols with p-toluenesulfonylmethyl isocyanide (TosMIC): dual roles of TosMIC.
A new silver-catalyzed heteroaromatization of propargylic alcohols with p-toluenesulfonylmethyl isocyanide (TosMIC) has been developed that provides an efficient and modular approach to sulfonylExpand
Catalytic C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds.
TLDR
A copper(I)-catalyzed, regioselective C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds using Togni's reagent was developed, which stereospecifically afforded the corresponding (E)-α-trIFluorometrichylated products in moderate to high yields. Expand
Silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides: divergent synthesis of indolizines and pyrroles.
TLDR
Divergent syntheses by the silver-catalyzed cyclization of 2-pyridyl alkynyl carbinols with isocyanides provide an effective route to highly functionalized indolizines and 2,4-disubstituted pyrroles in good to excellent yields. Expand
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