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Phase Transitions in the Assembly of Multi-Valent Signaling Proteins
Cells are organized on length scales ranging from ångström to micrometres. However, the mechanisms by which ångström-scale molecular properties are translated to micrometre-scale macroscopic… Expand
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
Misfolded proteins can be degraded by selective autophagy. The prevailing view is that ubiquitin-tagged misfolded proteins are assembled into aggregates by the scaffold protein p62, and the… Expand
Structure of a Key Intermediate of the SMN Complex Reveals Gemin2's Crucial Function in snRNP Assembly
The SMN complex mediates the assembly of heptameric Sm protein rings on small nuclear RNAs (snRNAs), which are essential for snRNP function. Specific Sm core assembly depends on Sm proteins and snRNA… Expand
Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1
Vav proteins are guanine nucleotide exchange factors (GEFs) for Rho family GTPases. They control processes including T cell activation, phagocytosis, and migration of normal and transformed cells. We… Expand
Regulatory features of the trp operon and the crystal structure of the trp RNA-binding attenuation protein from Bacillus stearothermophilus.
Characterization of both the cis and trans -acting regulatory elements indicates that the Bacillus stearothermophilustrp operon is regulated by an attenuation mechanism similar to that which controls… Expand
Mitotic Implantation of the Transcription Factor Prospero via Phase Separation Drives Terminal Neuronal Differentiation.
Compacted heterochromatin blocks are prevalent in differentiated cells and present a barrier to cellular reprogramming. It remains obscure how heterochromatin remodeling is orchestrated during cell… Expand
Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein α-subunit
Heterotrimeric G protein α (Gα) subunits possess intrinsic GTPase activity that leads to functional deactivation with a rate constant of ≈2 min-1 at 30°C. GTP hydrolysis causes conformational changes… Expand
Structural and energetic mechanisms of cooperative autoinhibition and activation of vav1
Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation
Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in… Expand
Multivalent m6A motifs promote phase separation of YTHDF proteins
Dear Editor, Posttranscriptional modifications of coding and non-coding RNAs are prevalent in cells. N6-methyladenosine (mA) is the most abundant type of modification on eukaryotic messenger RNAs… Expand