• Publications
  • Influence
Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation
In Alzheimer's disease (AD), the mechanisms of neuronal loss remain largely unknown. Although tau pathology is closely correlated with neuronal loss, how its accumulation may lead to activation ofExpand
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Imbalance of Hsp70 family variants fosters tau accumulation
Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat‐shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest thatExpand
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Accelerated neurodegeneration through chaperone-mediated oligomerization of tau.
Aggregation of tau protein in the brain is associated with a class of neurodegenerative diseases known as tauopathies. FK506 binding protein 51 kDa (FKBP51, encoded by FKBP5) forms a mature chaperoneExpand
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Muscle-specific knockout of PKC-lambda impairs glucose transport and induces metabolic and diabetic syndromes.
  • Robert V Farese, M. Sajan, +10 authors M. Leitges
  • Medicine
  • The Journal of clinical investigation
  • 2007
Obesity, the metabolic syndrome, and type 2 diabetes mellitus (T2DM) are major global health problems. Insulin resistance is frequently present in these disorders, but the causes and effects of suchExpand
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A deuterohemin peptide extends lifespan and increases stress resistance in Caenorhabditis elegans
Abstract This group has invented a novel deuterohemin containing peptide deuterohemin-AlaHisThrValGluLys (DhHP-6), which has various biological activities including protection of murine ischemiaExpand
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Significant genetic differentiation between the Yellow Sea and East China Sea populations of cocktail shrimp Trachypenaeus curvirostris revealed by the mitochondrial DNA COI gene
Abstract The cocktail shrimp Trachypenaeus curvirostris is an ecologically and economically important shrimp species in the Yellow Sea and East China Sea. However, there is no information about itsExpand
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Comparison of salt tolerance between Cichorium intybus L. transformed with AtNHX1 or HvBADH1
Drought and salinity are two major limiting factors of plant growth and agricultural productivity. An efficient way to improve salt tolerance of plants is by expression of the Na+/H+ antiporter geneExpand
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DhHP-6 extends lifespan of Caenorhabditis elegans by enhancing nuclear translocation and transcriptional activity of DAF-16
Abstract Earlier studies have demonstrated that Deuterohaemin-AlaHisThrValGluLys (DhHP-6), a novel porphyrin-peptide, increases lifespan and enhances stress resistance of Caenorhabditis elegans. ToExpand
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Extensive increase of microarray signals in cancers calls for novel normalization assumptions
We analyzed 7 large Affymetrix datasets of pair-matched normal and cancer samples for cancers collected in the NCBI GEO database. Expand
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An Intersectional Study of LncRNAs and mRNAs Reveals the Potential Therapeutic Targets of Buyang Huanwu Decoction in Experimental Intracerebral Hemorrhage
Background/Aims: Both experimental and clinical studies have revealed satisfactory effects of the traditional Chinese formula Buyang Huanwu decoction (BYHWD) in improving post-intracerebralExpand
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